Regulation of mRNA translation is a rapid and effective means to couple changes in the
cellular environment with global rates of protein synthesis. In response to stresses, such as …

Abstract The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by
genetic alterations in upstream signaling molecules such as receptor tyrosine kinases …

Understanding cancer metastasis at the proteoform level is crucial for discovering previously
unknown protein biomarkers for cancer diagnosis and drug development. We present the …

Gene expression universally relies on protein synthesis, where ribosomes recognize and
decode the messenger RNA template by cycling through translation initiation, elongation …

Summary Bicarbonate (HCO 3−) ions maintain pH homeostasis in eukaryotic cells and serve
as a carbonyl donor to support cellular metabolism. However, whether the abundance of …

Abstract Human mRNA DeXD/H-box helicases are ubiquitous molecular motors that are
required for the majority of cellular processes that involve RNA metabolism. One of the most …

Eukaryotic gene expression is a complicated process primarily regulated at the levels of
gene transcription and mRNA translation. The latter involves four main steps: initiation …

Recent work has brought to light many different mechanisms of translation initiation that
function in cells in parallel to canonical cap‐dependent initiation. This has important …

Mechanistic target of rapamcyin (mTOR) is a central player in cell growth throughout the
organism. However, mTOR takes on an additional, more specialized role in the developed …

Altered lipid metabolism and aberrant protein translation are strongly associated with
cancerous outgrowth; however, the inter-regulation of these key processes is still …