Human serum albumin (HSA) is the most abundant protein in plasma, contributing actively to
oncotic pressure maintenance and fluid distribution between body compartments. HSA acts …

Oxidative stress and protein modifications are frequently observed in numerous disease
states. Glucose constitutes a vital nutrient necessary to cellular oxygen metabolism …

Protein function and flexibility is directly related to the native distribution of its structural
elements and any alteration in protein architecture leads to several abnormalities and …

Background D-ribose in cells and human serum participates in glycation of proteins resulting
in advanced glycation end products (AGEs) that affect cell metabolism and induce cell …

Glycation is a general spontaneous process in proteins which has significant impact on their
physical and functional properties. These changes in protein properties could be related to …

Due to recent developments in biochemical engineering and in the understanding of the
physiopathology of many diseases, therapeutic biologics are expected to become of …

Amyloids are a class of insoluble proteinaceous substances generally composed of linear
un-branched fibrils that are formed from misfolded proteins. Conformational diseases such …

Glycation is a nonenzymatic posttranslational modification (PTM) known to be increased in
the brains of hyperglycemic patients. Alpha-synuclein (αSN), a central player in the etiology …

The post-translational modification of proteins by nonenzymatic glycation (NEG) and the
accumulation of AGEs are the two underlying factors associated with the long-term …

Serum albumin is glycated in diabetic or hyperglycemic conditions. For in vitro experiments
bovine serum albumin (BSA) is employed as a transport protein. So, in this work, we aim to …