To fulfill the task of gas exchange, the lung possesses a huge inner surface and a tree-like
system of conducting airways ventilating the gas exchange area. During lung development …

Recent studies have shown that the respiratory system has an extensive ability to respond to
injury and regenerate lost or damaged cells. The unperturbed adult lung is remarkably …

The bone morphogenetic protein (BMP) signaling pathway, including antagonists, functions
in lung development and regeneration of tracheal epithelium from basal stem cells. Here, we …

Gas exchange in the lung occurs within alveoli, air-filled sacs composed of type 2 and type 1
epithelial cells (AEC2s and AEC1s), capillaries, and various resident mesenchymal cells …

Interest in the contribution of changes in lung development during early life to subsequent
respiratory morbidity is increasing. Most evidence of an association between adverse …

To investigate the role of immune cells in lung regeneration, we used a unilateral
pneumonectomy model that promotes the formation of new alveoli in the remaining lobes …

Air pollution exposure has increased extensively in recent years and there is considerable
evidence that exposure to particulate matter can lead to adverse respiratory outcomes. The …

The pulmonary alveolar epithelium undergoes extensive regeneration in response to lung
injuries, including lung resection. In recent years, our understanding of cell lineage …

Developing, regenerating, and repairing a lung all require interstitial resident fibroblasts
(iReFs) to direct the behavior of the epithelial stem cell niche. During lung development …

The rapid expansion of the elderly population has led to the recent epidemic of age-related
diseases, including increased incidence and mortality of chronic and acute lung diseases …