Red blood cells (RBC) are the most abundant cell in the human body, with a central role in
oxygen transport and its delivery to tissues. However, omics technologies recently revealed …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

The SARS-CoV-2 beta coronavirus is the etiological driver of COVID-19 disease, which is
primarily characterized by shortness of breath, persistent dry cough, and fever. Because they …

Hypoxia occurs naturally at high-altitudes and pathologically in hypoxic solid tumors. Here,
we report that genes involved in various human cancers evolved rapidly in Tibetans and six …

Red blood cell (RBC) metabolic reprogramming upon exposure to high altitude contributes
to physiological human adaptations to hypoxia, a multifaceted process critical to health and …

Hypoxanthine catabolism in vivo is potentially dangerous as it fuels production of urate and,
most importantly, hydrogen peroxide. However, it is unclear whether accumulation of …

Fast changes in environmental oxygen availability translate into shifts in mitochondrial free
radical production. An increase in intraerythrocytic reduced glutathione (GSH) during …

Red blood cell transfusion is a life-saving intervention, and storage is a logistic necessity to
make~ 110 million units available for transfusion every year worldwide. However, storage in …

Hydrogen sulfide (H2S) has emerged as a gaseous signalling molecule with crucial
implications for cardiovascular health. H2S is involved in many biological functions …

Hypoxic tissue conditions occur during a number of inflammatory diseases and are
associated with the breakdown of barriers and induction of proinflammatory responses. At …