The role of alternative splicing coupled to nonsense-mediated mRNA decay in human disease

PJ da Costa, J Menezes, L Romão - … Journal of Biochemistry & Cell Biology, 2017 - Elsevier
Alternative pre-mRNA splicing (AS) affects gene expression as it generates proteome
diversity. Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that …

Splicing factor YBX1 regulates bone marrow stromal cell fate during aging

Y Xiao, GP Cai, X Feng, YJ Li, WH Guo, Q Guo… - The EMBO …, 2023 - embopress.org
Senescence and altered differentiation potential of bone marrow stromal cells (BMSCs) lead
to age‐related bone loss. As an important posttranscriptional regulatory pathway, alternative …

In sickness and in health: the role of TRAPP and associated proteins in disease

S Brunet, M Sacher - Traffic, 2014 - Wiley Online Library
Transport protein particle (TRAPP) represents a series of related protein complexes that
function in specific stages of inter‐organelle traffic. They share a core of subunits that can …

The application of multi-walled carbon nanotubes in bone tissue repair hybrid scaffolds and the effect on cell growth in vitro

J Xu, X Hu, S Jiang, Y Wang, R Parungao, S Zheng… - Polymers, 2019 - mdpi.com
In this study, composite scaffolds with different multi-walled carbon nanotubes (MWCNTs)
content were prepared by freeze-drying. These scaffolds were characterized by scanning …

Transcriptome sequencing of gingival biopsies from chronic periodontitis patients reveals novel gene expression and splicing patterns

YG Kim, M Kim, JH Kang, HJ Kim, JW Park, JM Lee… - Human genomics, 2016 - Springer
Background Periodontitis is the most common chronic inflammatory disease caused by
complex interaction between the microbial biofilm and host immune responses. In the …

Protein species as diagnostic markers

P Steffen, M Kwiatkowski, WD Robertson… - Journal of …, 2016 - Elsevier
Many diseases are associated with protein species perturbations. A prominent example of
an established diagnostic marker is the glycated protein species of hemoglobin, termed …

Gene expression and RNA splicing imputation identifies novel candidate genes associated with osteoporosis

Y Liu, H Shen, J Greenbaum, A Liu… - The Journal of …, 2020 - academic.oup.com
Context Though genome-wide association studies (GWASs) have identified hundreds of
genetic variants associated with osteoporosis related traits, such as bone mineral density …

Synovial and cartilage responsiveness to peri‐operative hyaluronic acid±dexamethasone administration following a limited injury to the rabbit stifle joint

BJ Heard, KI Barton, S Abubacker… - Journal of …, 2022 - Wiley Online Library
Posttraumatic osteoarthritis (PTOA) can develop after an injury to the knee. Previous studies
have indicated that an intra‐articular (IA) injection of the potent glucocorticoid …

Collagenase 1A2 (COL1A2) gene A/C polymorphism in relation to severity of dental fluorosis

D Escobar‐García, J Mejía‐Saavedra… - … dentistry and oral …, 2016 - Wiley Online Library
Objectives The aim of this study was to evaluate the putative association between the
presence of the COL 1A2 gene A/C polymorphism and the severity of dental fluorosis in a …

Farnesyl diphosphate synthase promotes cell proliferation by regulating gene expression and alternative splicing profiles in HeLa cells

L Wang, Z Chen, D Chen, B Kan, Y He… - Oncology …, 2023 - spandidos-publications.com
Farnesyl diphosphate synthase (FDPS), an essential enzyme involved in the mevalonate
pathway, is implicated in various diseases, including multiple types of cancer. As an RNA …