Krüppel-like factors (KLFs) are a family of zinc-finger transcription factors that are found in
many species. Recent studies have shown that KLFs play a fundamental role in regulating …

Expression of a few master transcription factors can reprogram the epigenetic landscape
and three-dimensional chromatin topology of differentiated cells and achieve pluripotency …

Intracellular delivery of mRNA, DNA, and other large macromolecules into cells plays an
essential role in an array of biological research and clinical therapies. However, current …

Somatic cells and pluripotent cells display remarkable differences in most aspects of cell
function. Accordingly, somatic cell reprogramming by exogenous factors requires …

Reprogramming human fibroblasts to induced pluripotent stem cells (iPSCs) is inefficient,
with heterogeneity among transcription factor (TF) trajectories driving divergent cell states …

Reprogramming is a dynamic process that can result in multiple pluripotent cell types
emerging from divergent paths. Cell surface protein expression is a particularly desirable …

Transgene-free induced pluripotent stem cells (iPSCs) are valuable for both basic research
and potential clinical applications. We previously reported that a replication-defective and …

Metabolite exchange between stromal and tumor cells or among tumor cells themselves
accompanies metabolic reprogramming in cancer including pancreatic adenocarcinoma …

We previously reported the generation of integration-free induced pluripotent stem cells from
adult peripheral blood (PB) with an improved episomal vector (EV) system, which uses the …

Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) is accompanied
by morphological, functional, and metabolic alterations before acquisition of full …