Fifty Years of Research in ARDS.Gas Exchange in Acute Respiratory Distress Syndrome

P Radermacher, SM Maggiore… - American journal of …, 2017 - atsjournals.org
Acute respiratory distress syndrome (ARDS) is characterized by severe impairment of gas
exchange. Hypoxemia is mainly due to intrapulmonary shunt, whereas increased alveolar …

Unrecognized suffering in the ICU: addressing dyspnea in mechanically ventilated patients

M Schmidt, RB Banzett, M Raux… - Intensive care …, 2014 - Springer
Background Intensive care unit (ICU) patients are exposed to many sources of discomfort.
Although increasing attention is being given to the detection and treatment of pain, very little …

Spontaneous breathing during lung-protective ventilation in an experimental acute lung injury model: high transpulmonary pressure associated with strong …

T Yoshida, A Uchiyama, N Matsuura… - Critical care …, 2012 - journals.lww.com
Objective: We investigated whether potentially injurious transpulmonary pressure could be
generated by strong spontaneous breathing and exacerbate lung injury even when plateau …

The comparison of spontaneous breathing and muscle paralysis in two different severities of experimental lung injury

T Yoshida, A Uchiyama, N Matsuura… - Critical care …, 2013 - journals.lww.com
Objectives: The benefits of spontaneous breathing over muscle paralysis have been proven
mainly in mild lung injury; no one has yet evaluated the effects of spontaneous breathing in …

Dyspnea in mechanically ventilated critically ill patients

M Schmidt, A Demoule, A Polito, R Porchet… - Critical care …, 2011 - journals.lww.com
Objectives: Ensuring the comfort of intensive care unit patients is crucial. Although control of
pain has been extensively addressed in this setting, data on dyspnea in mechanically …

Monitoring lung injury severity and ventilation intensity during mechanical ventilation

E Rezoagli, JG Laffey, G Bellani - Seminars in Respiratory and …, 2022 - thieme-connect.com
Acute respiratory distress syndrome (ARDS) is a severe form of respiratory failure burden by
high hospital mortality. No specific pharmacologic treatment is currently available and its …

Hypoxia-induced inflammation in the lung: a potential therapeutic target in acute lung injury?

S Fröhlich, J Boylan, P McLoughlin - American journal of respiratory …, 2013 - atsjournals.org
Acute lung injury (ALI) is a severe form of hypoxic lung disease responsible for a large
number of deaths worldwide. Despite recent advances in supportive care, no reduction in …

Management and outcome of mechanically ventilated patients after cardiac arrest

Y Sutherasan, O Peñuelas, A Muriel, M Vargas… - Critical Care, 2015 - Springer
Introduction The aim of this study was to describe and compare the changes in ventilator
management and complications over time, as well as variables associated with 28-day …

Noisy pressure support ventilation: a pilot study on a new assisted ventilation mode in experimental lung injury

MG de Abreu, PM Spieth, P Pelosi… - Critical care …, 2008 - journals.lww.com
Objective: To describe and evaluate the effects of the new noisy pressure support ventilation
(noisy PSV) on lung physiologic variables. Design: Crossover design with four modes of …

Pressure support improves oxygenation and lung protection compared to pressure-controlled ventilation and is further improved by random variation of pressure …

PM Spieth, AR Carvalho, A Güldner… - Critical care …, 2011 - journals.lww.com
Objectives: To explore whether 1) conventional pressure support ventilation improves lung
function and attenuates the pulmonary inflammatory response compared to pressure …