Perinatal nutritional and metabolic pathways: early origins of chronic lung diseases

C Kuiper-Makris, J Selle, E Nüsken, J Dötsch… - Frontiers in …, 2021 - frontiersin.org
Lung development is not completed at birth, but expands beyond infancy, rendering the lung
highly susceptible to injury. Exposure to various influences during a critical window of organ …

Monoclonal antibodies and airway diseases

A Lyly, A Laulajainen-Hongisto, P Gevaert… - International Journal of …, 2020 - mdpi.com
Monoclonal antibodies, biologics, are a relatively new treatment option for severe chronic
airway diseases, asthma, allergic rhinitis, and chronic rhinosinusitis (CRS). In this review, we …

[HTML][HTML] Serum myostatin levels and skeletal muscle wasting in chronic obstructive pulmonary disease

CR Ju, RC Chen - Respiratory Medicine, 2012 - Elsevier
INTRODUCTION: It is well confirmed that myostatin is a negative regulator of skeletal muscle
mass and implicated in several diseases involved in muscle wasting and cachexia. Skeletal …

Long non‑coding RNA maternally expressed gene regulates cigarette smoke extract induced lung inflammation and human bronchial epithelial apoptosis via miR‑149 …

Z Lei, H Guo, S Zou, J Jiang… - Experimental and …, 2021 - spandidos-publications.com
Chronic obstructive pulmonary disease (COPD) has become a significant public health risk.
Long non‑coding RNAs (lncRNAs) have been identified as important factors involved in the …

Cytokine and cytokine receptor single-nucleotide polymorphisms predict risk for non–small cell lung cancer among women

AL Van Dyke, ML Cote, AS Wenzlaff, W Chen… - … Biomarkers & Prevention, 2009 - AACR
Studies on the relationships between inflammatory pathway genes and lung cancer risk
have not included African-Americans and have only included a handful of genes. In a …

Carbocisteine attenuates TNF-α-induced inflammation in human alveolar epithelial cells in vitro through suppressing NF-κB and ERK1/2 MAPK signaling pathways

W Wang, W Guan, R Huang, Y Xie, J Zheng… - Acta Pharmacologica …, 2016 - nature.com
Aim: We previously proven that carbocisteine, a conventional mucolytic drug, remarkably
reduced the rate of acute exacerbations and improved the quality of life in the patients with …

Targeting the TNF-α pathway in sarcoidosis

SA Antoniu - Expert opinion on therapeutic targets, 2010 - Taylor & Francis
Importance of the field/Significance: Sarcoidosis is a granulomatous disease with various
organ manifestations in which TNF-α has been demonstrated to play a major pathogenic …

Superoxide release from contracting skeletal muscle in pulmonary TNF-α overexpression mice

L Zuo, AH Hallman, WJ Roberts… - American Journal …, 2014 - journals.physiology.org
Chronic obstructive pulmonary disease (COPD) often results in increased levels of tumor
necrosis factor-α (TNF-α), a proinflammatory cytokine, which circulates in the blood …

Células inflamatórias e seus mediadores na patogênese da DPOC

CH Costa, R Rufino, JR Lapa e Silva - Revista da Associação Médica …, 2009 - SciELO Brasil
A doença pulmonar obstrutiva crônica (DPOC) é causada por processo inflamatório crônico
que limita o fluxo aéreo, sendo sua principal causa o tabagismo. Conforme dados da …

[HTML][HTML] Inflammatory effects induced by selected limonene oxidation products: 4-OPA, IPOH, 4-AMCH in human bronchial (16HBE14o-) and alveolar (A549) epithelial …

D Lipsa, P Leva, J Barrero-Moreno, M Coelhan - Toxicology Letters, 2016 - Elsevier
Limonene, a monoterpene abundantly present in most of the consumer products (due to its
pleasant citrus smell), easily undergoes ozonolysis leading to several limonene oxidation …