Executive summary “Depression is a disorder of mood, so mysteriously painful and elusive
in the way it becomes known to the self—to the mediating intellect—as to verge close to …

Major depression is one of the most prevalent and debilitating personal and public health
conditions worldwide. Less appreciated is that depression's tremendous burdens are not …

Major depression is a leading contributor to the global burden of disease. This situation is
mainly related to the chronicity and/or recurrence of the disorder, and to poor response to …

Leading biological hypotheses propose that biological changes may underlie major
depressive disorder onset and relapse/recurrence. Here, we investigate if there is …

The increase of mental health problems and the need for effective medical health care have
led to an investigation of machine learning that can be applied in mental health problems …

Background Adolescent depression may increase risk for poor mental health outcomes in
adulthood. The objective of this study was to systematically review the literature on the …

The classical psychedelic drugs, including psilocybin, lysergic acid diethylamide and
mescaline, were used extensively in psychiatry before they were placed in Schedule I of the …

Abstract Background Prefrontal Transcranial Magnetic Stimulation (TMS) therapy repeated
daily over 4–6 weeks (20–30 sessions) is US Food and Drug Administration (FDA) approved …

Purpose To review and synthesise prognostic indices that predict subsequent risk,
prescriptive indices that moderate treatment response, and mechanisms that underlie each …

Objective: No recent meta-analysis has examined the effects of cognitive-behavioural
therapy (CBT) for adult depression. We decided to conduct such an updated meta-analysis …