Alternatives to conventional antibiotics in the era of antimicrobial resistance

C Ghosh, P Sarkar, R Issa, J Haldar - Trends in microbiology, 2019 - cell.com
As more antibiotics are rendered ineffective by drug-resistant bacteria, focus must be shifted
towards alternative therapies for treating infections. Although several alternatives already …

Kinases as potential therapeutic targets for anti-coronaviral therapy

T Pillaiyar, S Laufer - Journal of Medicinal Chemistry, 2021 - ACS Publications
The global coronavirus disease-19 (COVID-19) has affected more than 140 million and
killed more than 3 million people worldwide as of April 20, 2021. The novel human severe …

Broad-spectrum antiviral agents: a crucial pandemic tool

A Adalja, T Inglesby - Expert review of Anti-infective Therapy, 2019 - Taylor & Francis
Among the myriad infectious disease threats humans face from bacteria, prions, parasites,
protozoa, fungi, ectoparasites, and viruses, it is viral infections that arguably constitute the …

Anticancer and antiviral properties of cardiac glycosides: a review to explore the mechanism of actions

D Reddy, R Kumavath, D Barh, V Azevedo, P Ghosh - Molecules, 2020 - mdpi.com
Cardiac glycosides (CGs) have a long history of treating cardiac diseases. However, recent
reports have suggested that CGs also possess anticancer and antiviral activities. The …

SARS-CoV-2 and SARS-CoV differ in their cell tropism and drug sensitivity profiles

D Bojkova, JE McGreig, KM McLaughlin, SG Masterson… - BioRxiv, 2020 - biorxiv.org
SARS-CoV-2 is a novel coronavirus currently causing a pandemic. We show that the
majority of amino acid positions, which differ between SARS-CoV-2 and the closely related …

Lung cancer models reveal severe acute respiratory syndrome coronavirus 2–induced epithelial-to-mesenchymal transition contributes to coronavirus disease 2019 …

CA Stewart, CM Gay, K Ramkumar, KR Cargill… - Journal of Thoracic …, 2021 - Elsevier
Introduction Coronavirus disease 2019 is an infectious disease caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), which enters host cells through the cell …

Drug repurposing for new, efficient, broad spectrum antivirals

M García-Serradilla, C Risco, B Pacheco - Virus research, 2019 - Elsevier
Emerging viruses are a major threat to human health. Recent outbreaks have emphasized
the urgent need for new antiviral treatments. For several pathogenic viruses, considerable …

How glycosylation affects glycosylation: the role of N-glycans in glycosyltransferase activity

K Mikolajczyk, R Kaczmarek, M Czerwinski - Glycobiology, 2020 - academic.oup.com
N-glycosylation is one of the most important posttranslational modifications of proteins. It
plays important roles in the biogenesis and functions of proteins by influencing their folding …

The antiviral effects of Na, K-ATPase inhibition: a minireview

L Amarelle, E Lecuona - International journal of molecular sciences, 2018 - mdpi.com
Since being first described more than 60 years ago, Na, K-ATPase has been extensively
studied, while novel concepts about its structure, physiology, and biological roles continue to …

Structures of the SARS-CoV-2 spike glycoprotein and applications for novel drug development

XH Liu, T Cheng, BY Liu, J Chi, T Shu… - Frontiers in …, 2022 - frontiersin.org
COVID-19 caused by SARS-CoV-2 has raised a health crisis worldwide. The high morbidity
and mortality associated with COVID-19 and the lack of effective drugs or vaccines for SARS …