Primary aldosteronism is characterized by aldosterone secretion that is independent of renin
and angiotensin II and sodium status. The deleterious effects of primary aldosteronism are …

Early diagnosis and appropriate treatment of primary aldosteronism, the most frequent
cause of secondary hypertension, are crucial to prevent deleterious cardiovascular …

Objective Develop a consensus for the nomenclature and definition of adrenal
histopathologic features in unilateral primary aldosteronism (PA). Context Unilateral PA is …

Primary aldosteronism (PA) represents the most common cause of secondary hypertension,
but little is known regarding its adrenal cellular origins. Recently, aldosterone-producing cell …

Primary aldosteronism is considered the commonest cause of secondary hypertension. In
affected individuals, aldosterone is produced in an at least partially autonomous fashion in …

The final enzymes in the biosynthesis of aldosterone and cortisol are by the cytochrome
P450 CYP11B2 and CYP11B1, respectively. The enzymes are 93% homologous at the …

Primary aldosteronism is the most common form of secondary hypertension. Mutations in the
KCNJ5 gene have been described recently in aldosterone-producing adenomas (APAs) …

Childhood neuroblastoma has a remarkable variability in outcome. Age at diagnosis is one
of the most important prognostic factors, with children less than 1 year old having favorable …

Primary aldosteronism affects up to 10% of hypertensive patients and is responsible for
treatment resistance and increased cardiovascular risk. Here we perform a genome-wide …

Primary aldosteronism is the most common single cause of hypertension and is potentially
curable when only one adrenal gland is the culprit. The importance of primary aldosteronism …