Towards antivirals against chikungunya virus

R Abdelnabi, J Neyts, L Delang - Antiviral research, 2015 - Elsevier
Chikungunya virus (CHIKV) has re-emerged in recent decades, causing major outbreaks of
chikungunya fever in many parts of Africa and Asia, and since the end of 2013 also in …

Chikungunya virus

DM Vu, D Jungkind… - Clinics in laboratory …, 2017 - labmed.theclinics.com
Chikungunya virus (CHIKV) belongs to the Semliki Forest antigenic group of the genus
Alphaviridae, which includes other arthritogenic alphaviruses, such as o'nyong-nyong, Ross …

Current strategies for inhibition of chikungunya infection

BB Subudhi, S Chattopadhyay, P Mishra, A Kumar - Viruses, 2018 - mdpi.com
Increasing incidences of Chikungunya virus (CHIKV) infection and co-infections with
Dengue/Zika virus have highlighted the urgency for CHIKV management. Failure in …

Antivirals against the Chikungunya virus

V Battisti, E Urban, T Langer - Viruses, 2021 - mdpi.com
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that has re-emerged in
recent decades, causing large-scale epidemics in many parts of the world. CHIKV infection …

Current and promising antivirals against chikungunya virus

FIL Hucke, JJ Bugert - Frontiers in Public Health, 2020 - frontiersin.org
Chikungunya virus (CHIKV) is the causative agent of chikungunya fever (CHIKF) and is
categorized as a (n)(re) emerging arbovirus. CHIKV has repeatedly been responsible for …

Current status of chikungunya in India

… Consortia (TRC) for Chikungunya Virus in … - Frontiers in …, 2021 - frontiersin.org
Chikungunya fever (CHIKF) is an arbovirus disease caused by chikungunya virus (CHIKV),
an alphavirus of Togaviridae family. Transmission follows a human-mosquito-human cycle …

Design and validation of novel chikungunya virus protease inhibitors

PK Das, L Puusepp, FS Varghese, A Utt… - Antimicrobial agents …, 2016 - Am Soc Microbiol
Chikungunya virus (CHIKV; genus Alphavirus) is the causative agent of chikungunya fever.
CHIKV replication can be inhibited by some broad-spectrum antiviral compounds; in …

[HTML][HTML] Inhibition of chikungunya virus by picolinate that targets viral capsid protein

R Sharma, B Fatma, A Saha, S Bajpai, S Sistla… - Virology, 2016 - Elsevier
The protein-protein interactions (PPIs) of the transmembrane glycoprotein E2 with the
hydrophobic pocket on the surface of capsid protein (CP) plays a critical role in alphavirus …

Computer-aided design, synthesis, and antiviral evaluation of novel acrylamides as potential inhibitors of E3-E2-E1 glycoproteins complex from chikungunya virus

GFS Passos, MGM Gomes, TM Aquino… - Pharmaceuticals, 2020 - mdpi.com
Chikungunya virus (CHIKV) causes an infectious disease characterized by inflammation and
pain of the musculoskeletal tissues accompanied by swelling in the joints and cartilage …

Chikungunya virus infectivity, RNA replication and non-structural polyprotein processing depend on the nsP2 protease's active site cysteine residue

K Rausalu, A Utt, T Quirin, FS Varghese, E Žusinaite… - Scientific reports, 2016 - nature.com
Chikungunya virus (CHIKV), genus Alphavirus, family Togaviridae, has a positive-stand
RNA genome approximately 12 kb in length. In infected cells, the genome is translated into …