Autism spectrum disorder: neurodevelopmental risk factors, biological mechanism, and precision therapy
L Wang, B Wang, C Wu, J Wang, M Sun - International journal of …, 2023 - mdpi.com
Autism spectrum disorder (ASD) is a heterogeneous, behaviorally defined
neurodevelopmental disorder. Over the past two decades, the prevalence of autism …
neurodevelopmental disorder. Over the past two decades, the prevalence of autism …
Autism spectrum disorder: neuropathology and animal models
M Varghese, N Keshav, S Jacot-Descombes… - Acta …, 2017 - Springer
Autism spectrum disorder (ASD) has a major impact on the development and social
integration of affected individuals and is the most heritable of psychiatric disorders. An …
integration of affected individuals and is the most heritable of psychiatric disorders. An …
The ASD Living Biology: from cell proliferation to clinical phenotype
E Courchesne, T Pramparo, VH Gazestani… - Molecular …, 2019 - nature.com
Autism spectrum disorder (ASD) has captured the attention of scientists, clinicians and the
lay public because of its uncertain origins and striking and unexplained clinical …
lay public because of its uncertain origins and striking and unexplained clinical …
A selective review of the excitatory-inhibitory imbalance in schizophrenia: underlying biology, genetics, microcircuits, and symptoms
Y Liu, P Ouyang, Y Zheng, L Mi, J Zhao… - Frontiers in cell and …, 2021 - frontiersin.org
Schizophrenia is a chronic disorder characterized by specific positive and negative primary
symptoms, social behavior disturbances and cognitive deficits (eg, impairment in working …
symptoms, social behavior disturbances and cognitive deficits (eg, impairment in working …
Ovarian hormones organize the maturation of inhibitory neurotransmission in the frontal cortex at puberty onset in female mice
The frontal cortex matures late in development, showing dramatic changes after puberty
onset, yet few experiments have directly tested the role of pubertal hormones in cortical …
onset, yet few experiments have directly tested the role of pubertal hormones in cortical …
Mechanisms underlying circuit dysfunction in neurodevelopmental disorders
D Exposito-Alonso, B Rico - Annual Review of Genetics, 2022 - annualreviews.org
Recent advances in genomics have revealed a wide spectrum of genetic variants
associated with neurodevelopmental disorders at an unprecedented scale. An increasing …
associated with neurodevelopmental disorders at an unprecedented scale. An increasing …
Upregulation of SYNGAP1 expression in mice and human neurons by redirecting alternative splicing
Summary The Ras GTPase-activating protein SYNGAP1 plays a central role in synaptic
plasticity, and de novo SYNGAP1 mutations are among the most frequent causes of autism …
plasticity, and de novo SYNGAP1 mutations are among the most frequent causes of autism …
Essential genetic findings in neurodevelopmental disorders
AR Cardoso, M Lopes-Marques, RM Silva, C Serrano… - Human genomics, 2019 - Springer
Neurodevelopmental disorders (NDDs) represent a growing medical challenge in modern
societies. Ever-increasing sophisticated diagnostic tools have been continuously revealing a …
societies. Ever-increasing sophisticated diagnostic tools have been continuously revealing a …
Cortical interneurons in autism
The mechanistic underpinnings of autism remain a subject of debate and controversy. Why
do individuals with autism share an overlapping set of atypical behaviors and symptoms …
do individuals with autism share an overlapping set of atypical behaviors and symptoms …
Comprehensive behavioral analysis of heterozygous Syngap1 knockout mice
Abstract Aims Synaptic Ras GTPase‐activating protein 1 (SYNGAP1) regulates synaptic
plasticity through AMPA receptor trafficking. SYNGAP1 mutations have been found in human …
plasticity through AMPA receptor trafficking. SYNGAP1 mutations have been found in human …