ImmunoPET: concept, design, and applications

W Wei, ZT Rosenkrans, J Liu, G Huang, QY Luo… - Chemical …, 2020 - ACS Publications
Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …

[HTML][HTML] CD248: A therapeutic target in cancer and fibrotic diseases

BA Teicher - Oncotarget, 2019 - ncbi.nlm.nih.gov
Abstract CD248/endosialin/TEM1 is a type 1 transmembrane glycoprotein found on the
plasma membrane of activated mesenchymal cells. CD248 functions during embryo …

[HTML][HTML] CXCL12 derived from CD248-expressing cancer-associated fibroblasts mediates M2-polarized macrophages to promote nonsmall cell lung cancer …

J Wu, X Liu, J Wu, C Lou, Q Zhang, H Chen… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Nonsmall cell lung cancer (NSCLC) is among the most prevalent malignant tumours
threatening human health. In the tumour microenvironment (TME), cancer-associated …

Noninvasive interrogation of DLL3 expression in metastatic small cell lung cancer

SK Sharma, J Pourat, D Abdel-Atti, SD Carlin… - Cancer research, 2017 - AACR
The Notch ligand DLL3 has emerged as a novel therapeutic target expressed in small cell
lung cancer (SCLC) and high-grade neuroendocrine carcinomas. Rovalpituzumab teserine …

T cells bearing a chimeric antigen receptor against prostate-specific membrane antigen mediate vascular disruption and result in tumor regression

SP Santoro, S Kim, GT Motz, D Alatzoglou, C Li… - Cancer immunology …, 2015 - AACR
Aberrant blood vessels enable tumor growth, provide a barrier to immune infiltration, and
serve as a source of protumorigenic signals. Targeting tumor blood vessels for destruction …

CD248/endosialin critically regulates hepatic stellate cell proliferation during chronic liver injury via a PDGF-regulated mechanism

A Wilhelm, V Aldridge, D Haldar, AJ Naylor, CJ Weston… - Gut, 2016 - gut.bmj.com
Introduction CD248 (endosialin) is a stromal cell marker expressed on fibroblasts and
pericytes. During liver injury, myofibroblasts are the main source of fibrotic matrix. Objective …

[HTML][HTML] Endosialin in cancer: Expression patterns, mechanistic insights, and therapeutic approaches

S Lu, L Gan, T Lu, K Zhang, J Zhang, X Wu, D Han… - Theranostics, 2024 - ncbi.nlm.nih.gov
Endosialin, also known as tumor endothelial marker 1 (TEM1) or CD248, is a single
transmembrane glycoprotein with a C-type lectin-like domain. Endosialin is mainly …

Theranostic probes for targeting tumor microenvironment: an overview

MG Sikkandhar, AM Nedumaran… - International journal of …, 2017 - mdpi.com
Long gone is the time when tumors were thought to be insular masses of cells, residing
independently at specific sites in an organ. Now, researchers gradually realize that tumors …

Soluble trivalent engagers redirect cytolytic T cell activity toward tumor endothelial marker 1

JK Fierle, M Brioschi, M de Tiani, L Wetterwald… - Cell Reports …, 2021 - cell.com
Summary Tumor endothelial marker 1 (TEM1) is an emerging cancer target with a unique
dual expression profile. First, TEM1 is expressed in the stroma and neo-vasculature of many …

[HTML][HTML] Tumour endothelial marker 1/endosialin-mediated targeting of human sarcoma

Y Guo, J Hu, Y Wang, X Peng, J Min, J Wang… - European Journal of …, 2018 - Elsevier
Background Tumour endothelial marker 1 (TEM1/endosialin/CD248) is a tumour-restricted
cell-surface protein expressed by human sarcomas. We previously developed a high-affinity …