Initially described as effectors of natural cytotoxicity and critical players for the control of viral
infections and tumor growth, recent investigations unraveled more widespread functions for …

Head and neck squamous cell carcinoma (HNSCC) arises in the oral cavity, salivary glands,
larynx, pharynx, nasal cavity and paranasal sinuses, and is characterized by high morbidity …

The mechanism underlying persistent hepatitis B virus (HBV) infection remains unclear. We
investigated the role of innate immune responses to persistent HBV infection in 154 HBV …

In the immunological surveillance against cancer, natural killer (NK) cells are essential
effectors that help eradicate altered cells. The complex interactions that occur between NK …

Abstract Knowledge of the interactions between MHC-unrestricted cytotoxic effector cells
and solid tumour cells is essential for introducing more effective NK cell-based …

Natural killer (NK) cells are crucial components of the innate immune system, providing the
first line of defense against infectious pathogens and tumors. Interleukin (IL)-12 is an …

Neuroblastoma (NB) is the most common solid extracranial tumor in childhood. Despite
therapeutic progress, prognosis in high-risk NB is poor and innovative therapies are urgently …

Anti-PD-1/PD-L1 therapy has shown significant benefits in the treatment of a variety of
malignancies. However, not all cancer patients can benefit from this strategy due to drug …

The activating killer cell lectin-like receptor NKG2D plays a key role in the natural killer (NK)
cell-mediated lysis of tumours and infected cells. Unlike other receptors, the ligands …

Abstract Learning Objectives After completing this course, the reader will be able to:
Describe the current in vivo experimental and clinical dendritic cell (DC) vaccination studies …