Preeclampsia: pathophysiology, challenges, and perspectives

S Rana, E Lemoine, JP Granger… - Circulation …, 2019 - Am Heart Assoc
Hypertensive disorders of pregnancy—chronic hypertension, gestational hypertension, and
preeclampsia—are uniquely challenging as the pathology and its therapeutic management …

Pre-eclampsia: pathophysiology and clinical implications

GJ Burton, CW Redman, JM Roberts, A Moffett - Bmj, 2019 - bmj.com
Pre-eclampsia is a common disorder that particularly affects first pregnancies. The clinical
presentation is highly variable but hypertension and proteinuria are usually seen. These …

Pre-eclampsia: its pathogenesis and pathophysiolgy: review articles

P Gathiram, J Moodley - Cardiovascular journal of Africa, 2016 - journals.co.za
Pre-eclampsia is a pregnancy-specific disorder that has a worldwide prevalence of 5-8%. It
is one of the main causes of maternal and perinatal morbidity and mortality globally and …

Preeclampsia: novel mechanisms and potential therapeutic approaches

Z Armaly, JE Jadaon, A Jabbour, ZA Abassi - Frontiers in physiology, 2018 - frontiersin.org
Preeclampsia is a serious complication of pregnancy where it affects 5–8% of all
pregnancies. It increases the morbidity and mortality of both the fetus and pregnant woman …

Hypoxia and reproductive health: Oxygen and development of the human placenta

GJ Burton, T Cindrova-Davies, H wa Yung… - …, 2021 - rep.bioscientifica.com
Development of the human placenta takes place in contrasting oxygen concentrations at
different stages of gestation, from~ 20 mmHg during the first trimester rising to~ 60 mmHg at …

Mitochondrial–endoplasmic reticulum interactions in the trophoblast: stress and senescence

GJ Burton, HW Yung, AJ Murray - Placenta, 2017 - Elsevier
Placental stress has been implicated in the pathophysiology of complications of pregnancy,
including growth restriction and pre-eclampsia. Initially, attention focused on oxidative …

Differential activation of placental unfolded protein response pathways implies heterogeneity in causation of early‐and late‐onset pre‐eclampsia

HW Yung, D Atkinson, T Campion‐Smith… - The Journal of …, 2014 - Wiley Online Library
Based on gestational age at diagnosis and/or delivery, pre‐eclampsia (PE) is commonly
divided into early‐onset (< 34 weeks) and late‐onset (≥ 34 weeks) forms. Recently, the …

Preeclampsia: Disease biology and burden, its management strategies with reference to India

A Malik, B Jee, SK Gupta - Pregnancy hypertension, 2019 - Elsevier
Preeclampsia is the cause of significant maternal and fetal mortality and morbidity. It is
characterized by new-onset hypertension and proteinuria after 20 weeks of gestation …

Combined diffusion‐relaxometry MRI to identify dysfunction in the human placenta

PJ Slator, J Hutter, M Palombo… - Magnetic resonance …, 2019 - Wiley Online Library
Purpose A combined diffusion‐relaxometry MR acquisition and analysis pipeline for in vivo
human placenta, which allows for exploration of coupling between and apparent diffusion …

Functional imaging of the human placenta with magnetic resonance

N Siauve, GE Chalouhi, B Deloison, M Alison… - American journal of …, 2015 - Elsevier
Abnormal placentation is responsible for most failures in pregnancy; however, an
understanding of placental functions remains largely concealed from noninvasive, in vivo …