Compounds with polyfluorinated molecular fragments possess unique properties associated
with the presence of a large number of fluorine atoms that affect lipophilicity and …

Over the past decade, ruthenium-mediated metathesis transformations, including cross-
metathesis, ring-closing metathesis, enyne metathesis, ring-opening metathesis …

Cross-coupling of nitrogen with hydrocarbons under fragment coupling conditions stands to
significantly impact chemical synthesis. Herein, we disclose a C (sp3)–N fragment coupling …

Most breast and prostate tumors are hormone-dependent, making it possible to use
hormone therapy in patients with these tumors. The design of effective endocrine drugs that …

Selective agonism of the estrogen receptor (ER) subtypes, ERα and ERβ, has historically
been difficult to achieve due to the high degree of ligand-binding domain structural similarity …

The heptafluoroisopropyl group (CF (CF3) 2) is prevalent in pharmaceuticals and
agrichemicals. However, heptafluoroisopropoxylated (OCF (CF3) 2) compounds remain …

The isoperfluoropropyl group (i-C3F7) is an emerging motif in pharmaceuticals,
agrichemicals and functional materials. However, isoperfluoropropylated compounds …

While CF (CF3) 2-containing arenes are prevalent in pharmaceuticals and agrichemicals,
CF (CF3) 2-containing heteroarenes remain largely underexplored. Herein, we disclose the …

There were synthesized new types of ribbon type steroidal dimers derived from three types
of steroidal skeletons (cholic acid, etienic acid, estrone) using CuI catalyzed 1, 3-dipolar …

Oxidant-induced three-component hydro-, bromo-, and chloroheptafluoroisopropylation of
unactivated alkenes are disclosed. In these reactions, the CF (CF3) 2 radical was generated …