Axonal pathology in traumatic brain injury

VE Johnson, W Stewart, DH Smith - Experimental neurology, 2013 - Elsevier
Over the past 70 years, diffuse axonal injury (DAI) has emerged as one of the most common
and important pathological features of traumatic brain injury (TBI). Axons in the white matter …

Traumatic axonal injury: mechanisms and translational opportunities

CS Hill, MP Coleman, DK Menon - Trends in neurosciences, 2016 - cell.com
Traumatic axonal injury (TAI) is an important pathoanatomical subgroup of traumatic brain
injury (TBI) and a major driver of mortality and functional impairment. Experimental models …

Translational research in traumatic brain injury

D Laskowitz, G Grant - 2016 - books.google.com
Traumatic brain injury (TBI) remains a significant source of death and permanent disability,
contributing to nearly one-third of all injury related deaths in the United States and exacting …

[HTML][HTML] Mechanical breaking of microtubules in axons during dynamic stretch injury underlies delayed elasticity, microtubule disassembly, and axon degeneration

MD Tang-Schomer, AR Patel, PW Baas… - The FASEB …, 2010 - ncbi.nlm.nih.gov
Little is known about which components of the axonal cytoskeleton might break during rapid
mechanical deformation, such as occurs in traumatic brain injury. Here, we micropatterned …

Diffuse axonal injury and oxidative stress: a comprehensive review

A Frati, D Cerretani, AI Fiaschi, P Frati, V Gatto… - International journal of …, 2017 - mdpi.com
Traumatic brain injury (TBI) is one of the world's leading causes of morbidity and mortality
among young individuals. TBI applies powerful rotational and translational forces to the …

Brain neurotrauma: molecular, neuropsychological, and rehabilitation aspects

FH Kobeissy - 2015 - books.google.com
With the contribution from more than one hundred CNS neurotrauma experts, this book
provides a comprehensive and up-to-date account on the latest developments in the area of …

Axonal damage in traumatic brain injury

DH Smith, DF Meaney - The neuroscientist, 2000 - journals.sagepub.com
Axonal damage is one of the most common and important pathologic features of traumatic
brain injury. Severe diffuse axonal injury, resulting from inertial forces applied to the head, is …

Mild traumatic brain injury and diffuse axonal injury in swine

KD Browne, XH Chen, DF Meaney… - Journal of …, 2011 - liebertpub.com
Until recently, mild traumatic brain injury (mTBI) or “concussion” was generally ignored as a
major health issue. However, emerging evidence suggests that this injury is by no means …

Therapy development for diffuse axonal injury

DH Smith, R Hicks, JT Povlishock - Journal of neurotrauma, 2013 - liebertpub.com
Diffuse axonal injury (DAI) remains a prominent feature of human traumatic brain injury (TBI)
and a major player in its subsequent morbidity. The importance of this widespread axonal …

Experimental models of traumatic brain injury: do we really need to build a better mousetrap?

DM Morales, N Marklund, D Lebold, HJ Thompson… - Neuroscience, 2005 - Elsevier
Approximately 4000 human beings experience a traumatic brain injury each day in the
United States ranging in severity from mild to fatal. Improvements in initial management …