Proteolysis-targeting chimeras (PROTACs) are an emerging drug modality that may offer
new opportunities to circumvent some of the limitations associated with traditional small …

The success of mechanism-based drug discovery depends on the definition of the drug
target. This definition becomes even more important as we try to link drug response to …

Medicinal plants have historically proven their value as a source of molecules with
therapeutic potential, and nowadays still represent an important pool for the identification of …

The pharmaceutical industry remains under huge pressure to address the high attrition rates
in drug development. Attempts to reduce the number of efficacy-and safety-related failures …

Photopharmacology is a growing area of endeavor that employs photoswitchable ligands to
allow for light-dependent pharmacological activity. By coupling light to therapeutic action …

Natural products (NPs) are secondary metabolites produced and used by organisms for
defending or adapting purposes. These molecules were naturally selected during thousands …

The n-octanol/water partition coefficient (log P o/w) is a key physicochemical parameter for
drug discovery, design, and development. Here, we present a physics-based approach that …

The judicious application of ligand or binding efficiency metrics, which quantify the
molecular properties required to obtain binding affinity for a drug target, is gaining traction in …

The four-membered oxetane ring has been increasingly exploited for its contrasting
behaviors: its influence on physicochemical properties as a stable motif in medicinal …

The past 60 years have seen huge advances in many of the scientific, technological and
managerial factors that should tend to raise the efficiency of commercial drug research and …