Epithelial cells require apical–basal plasma membrane polarity to carry out crucial vectorial
transport functions and cytoplasmic polarity to generate different cell progenies for tissue …

Hepatocytes form a crucially important cell layer that separates sinusoidal blood from the
canalicular bile. They have a uniquely organized polarity with a basal membrane facing liver …

Disrupted cell polarity is a feature of epithelial cancers. The Crumbs, Par and Scribble
polarity complexes function to specify and maintain apical and basolateral membrane …

Epithelia within tubular organs form and expand lumens. Failure of these processes can
result in serious developmental anomalies. Although tight junction assembly is crucial to …

Signaling via the Rho GTPases provides crucial regulation of numerous cell polarization
events, including apicobasal (AB) polarity, polarized cell migration, polarized cell division …

In epithelial cells, the polarized orientation of the apical–basal axis determines the position
of the apical lumen and, thereby, the collective tubular tissue architecture. From recent …

Oriented cell divisions are critical for the formation and maintenance of structured epithelia.
Proper mitotic spindle orientation relies on polarised anchoring of force generators to the …

The PAR-1–MARK pathway controls cell polarity through the phosphorylation of microtubule-
associated proteins. Rho-Rac guanine nucleotide exchange factor 2 (ARHGEF2), which …

Hepatocytes, the main epithelial cell type of the liver, function like all epithelial cells to
mediate the vectorial flow of macromolecules into and out of the organ they encompass …

Lumen morphogenesis results from the interplay between molecular pathways and
mechanical forces. In several organs, epithelial cells share their apical surfaces to form a …