Endoplasmic reticulum quality control (ERQC) pathways comprising chaperones, folding
enzymes, and degradation factors ensure the fidelity of ER protein folding and trafficking to …

The endoplasmic reticulum (ER) represents the entry point into the secretory pathway where
nascent proteins encounter a specialized environment for their folding and maturation …

Most of the secreted and plasma membrane proteins are synthesized on membrane-bound
ribosomes on the endoplasmic reticulum (ER). They require engagement of ER-resident …

Hsp70 chaperones are central hubs of the protein quality control network and collaborate
with co-chaperones having a J-domain (an∼ 70-residue–long helical hairpin with a flexible …

Evidence suggests that caffeine (CF) reduces cardiovascular disease (CVD) risk. However,
the mechanism by which this occurs has not yet been uncovered. Here, we investigated the …

The unfolded protein response (UPR) detects the accumulation of unfolded proteins in the
endoplasmic reticulum (ER) and adjusts the protein-folding capacity to the needs of the cell …

The folding of many newly synthesized proteins in the cell depends on a set of conserved
proteins known as molecular chaperones. These prevent the formation of misfolded protein …

In crossing a heath, suppose... I had found a watch upon the ground, and it should be
inquired how the watch happened to be in that place....[T] he inference, we think, is …

Conformational diseases are caused by mutations altering the folding pathway or final
conformation of a protein. Many conformational diseases are caused by mutations in …

The endoplasmic reticulum (ER) has a quality-control system for'proof-reading'newly
synthesized proteins, so that only native conformers reach their final destinations. Non …