Correlative evidence suggests that polyploidization of heart muscle, which occurs naturally
in post-natal mammals, creates a barrier to heart regeneration. Here, we move beyond a …

The heart is one of the vital organs and is functionalized for blood circulation from its early
development. Some vertebrates have altered their living environment from aquatic to …

Heart regeneration is a fascinating and complex biological process. Decades of intensive
studies have revealed a sophisticated molecular network regulating cardiac regeneration in …

The inability of adult human cardiomyocytes to proliferate is an obstacle to efficient cardiac
regeneration after injury. Understanding the mechanisms that drive postnatal …

Chromatin remodeling plays an important role in regulating gene transcription, in which
chromatin remodeling complex is a crucial aspect. Brg1/Brm-associated factor 60c (BAF60c) …

Models of cardiac repair are needed to understand mechanisms underlying failure to
regenerate in human cardiac tissue. Such studies are currently dominated by the use of …

Axolotl (Ambystoma mexicanum) is a urodele amphibian endowed with remarkable
regenerative capacities manifested in scarless wound healing and restoration of amputated …

In the mammalian heart, cardiomyocytes are forced to withdraw from the cell cycle shortly
after birth, limiting the ability of the heart to regenerate and repair. The development of …

Understanding the remarkable capacity of vertebrates to naturally regenerate injured body
parts has great importance for potential translation into human therapeutic applications. As …

Abstract The Mexican axolotl (Ambystoma mexicanum) is a critically endangered species
and a fruitful amphibian model for regenerative biology. Despite growing body of research …