Recent advances in small molecular near-infrared fluorescence probes for a targeted diagnosis of the Alzheimer disease
Y Liu, D Zhuang, J Wang, H Huang, R Li, C Wu… - Analyst, 2022 - pubs.rsc.org
Nowadays, it is still quite challenging to achieve an early diagnosis of the Alzheimer disease
(AD) in clinics. The burgeoning near-infrared fluorescence (NIRF) imaging fulfills the …
(AD) in clinics. The burgeoning near-infrared fluorescence (NIRF) imaging fulfills the …
Benzofuran and indole: promising scaffolds for drug development in Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disease with no clinically
accepted treatment to cure or halt its progression. The Food and Drug Administration has …
accepted treatment to cure or halt its progression. The Food and Drug Administration has …
Design, synthesis, in silico and biological evaluations of novel polysubstituted pyrroles as selective acetylcholinesterase inhibitors against Alzheimer's disease
H Pourtaher, A Hasaninejad, A Iraji - Scientific Reports, 2022 - nature.com
The objective of this study was to design new polysubstituted pyrrole derivatives as selective
acetylcholinesterase (AChE) inhibitors to target Alzheimer's disease. In this context, a highly …
acetylcholinesterase (AChE) inhibitors to target Alzheimer's disease. In this context, a highly …
Design, synthesis, biological evaluation, and docking study of novel dual-acting thiazole-pyridiniums inhibiting acetylcholinesterase and β-amyloid aggregation for …
New compounds containing thiazole and pyridinium moieties were designed and
synthesized. The potency of the synthesized compounds as selective inhibitors of …
synthesized. The potency of the synthesized compounds as selective inhibitors of …
Synthesis and anticholinesterase activity of coumarin-3-carboxamides bearing tryptamine moiety
S Ghanei-Nasab, M Khoobi, F Hadizadeh… - European journal of …, 2016 - Elsevier
Abstract A number of N-(2-(1H-indol-3-yl) ethyl)-2-oxo-2H-chromene-3-carboxamides were
synthesized and tested against AChE and BuChE. The in vitro assessment of the …
synthesized and tested against AChE and BuChE. The in vitro assessment of the …
Advances in blood biomarkers for Alzheimer's disease: ultra-sensitive detection technologies and impact on clinical diagnosis
Y Zhang, K Bi, L Zhou, J Wang, L Huang… - Degenerative …, 2024 - Taylor & Francis
Alzheimer's disease has escalated into a critical public health concern, marked by its
neurodegenerative nature that progressively diminishes cognitive abilities. Recognized as a …
neurodegenerative nature that progressively diminishes cognitive abilities. Recognized as a …
Amyloid-β oligomer targeted theranostic probes for in vivo NIR imaging and inhibition of self-aggregation and amyloid-β induced ROS generation
To enable the early detection and intervention of Alzheimer's disease (AD), it is highly
desirable to develop novel theranostic agents for simultaneous detection of toxic and …
desirable to develop novel theranostic agents for simultaneous detection of toxic and …
Multitarget drug design strategy against Alzheimer's disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B …
Y Li, X Qiang, L Luo, X Yang, G Xiao, Y Zheng… - Bioorganic & Medicinal …, 2017 - Elsevier
A series of homoisoflavonoid Mannich base derivatives were designed, synthesized and
evaluated as multifunctional agents against Alzheimer's disease. It demonstrated that most …
evaluated as multifunctional agents against Alzheimer's disease. It demonstrated that most …
Donepezil-based central acetylcholinesterase inhibitors by means of a “bio-oxidizable” prodrug strategy: design, synthesis, and in vitro biological evaluation
L Peauger, R Azzouz, V Gembus… - Journal of medicinal …, 2017 - ACS Publications
With the aim of reducing side effects of acetylcholinesterase inhibitors (AChEIs) during
symptomatic treatment of Alzheimer's disease, we report herein a new class of donepezil …
symptomatic treatment of Alzheimer's disease, we report herein a new class of donepezil …
Design, synthesis and biological evaluation of novel coumarin-N-benzyl pyridinium hybrids as multi-target agents for the treatment of Alzheimer's disease
JS Lan, Y Ding, Y Liu, P Kang, JW Hou… - European Journal of …, 2017 - Elsevier
Combining N-benzyl pyridinium moiety and coumarin into in a single molecule, novel
hybrids with ChE and MAO-B inhibitory activities were designed and synthesized. The …
hybrids with ChE and MAO-B inhibitory activities were designed and synthesized. The …