Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders

B Dinda, S Dinda, S DasSharma, R Banik… - European journal of …, 2017 - Elsevier
Abstract The flavonoids, baicalin (5, 6-dihydroxy-2-phenyl-4H-1-benzopyran-4-one-7-Od-β-
glucuronic acid) 1 and its aglycone, baicalein 2 are found in edible medicinal plants …

[HTML][HTML] An overview of pharmacological activities of baicalin and its aglycone baicalein: New insights into molecular mechanisms and signaling pathways

Z Hu, Y Guan, W Hu, Z Xu, M Ishfaq - Iranian Journal of Basic …, 2022 - ncbi.nlm.nih.gov
The flavonoids, baicalin, and its aglycone baicalein possess multi-fold therapeutic properties
and are mainly found in the roots of Oroxylum indicum (L.) Kurz and Scutellaria baicalensis …

Inhibition of oxidative stress and ALOX12 and NF-κB pathways contribute to the protective effect of baicalein on carbon tetrachloride-induced acute liver injury

C Dai, H Li, Y Wang, S Tang, T Velkov, J Shen - Antioxidants, 2021 - mdpi.com
This study investigates the protective effect of baicalein on carbon tetrachloride (CCl4)-
induced acute liver injury and the underlying molecular mechanisms. Mice were orally …

Current status of herbal medicines in chronic liver disease therapy: the biological effects, molecular targets and future prospects

M Hong, S Li, HY Tan, N Wang, SW Tsao… - International journal of …, 2015 - mdpi.com
Chronic liver dysfunction or injury is a serious health problem worldwide. Chronic liver
disease involves a wide range of liver pathologies that include fatty liver, hepatitis, fibrosis …

Polyphenols by Generating H2O2, Affect Cell Redox Signaling, Inhibit PTPs and Activate Nrf2 Axis for Adaptation and Cell Surviving: In Vitro, In Vivo and Human …

J Kanner - Antioxidants, 2020 - mdpi.com
Human health benefits from different polyphenols molecules consumption in the diet,
derived mainly by their common activities in the gastrointestinal tract and at the level of …

Myricitrin exhibits antioxidant, anti-inflammatory and antifibrotic activity in carbon tetrachloride-intoxicated mice

R Domitrović, K Rashed, O Cvijanović… - Chemico-biological …, 2015 - Elsevier
Abstract Myricetin-3-O-α-rhamnoside (myricitrin) is a naturally occurring phenolic compound
which possesses antioxidant and anti-inflammatory activity. The aim of this study was to …

Role of flavonoids in management of inflammatory disorders

R Shukla, V Pandey, GP Vadnere, S Lodhi - Bioactive food as dietary …, 2019 - Elsevier
Flavonoids are a wide category of polyphenolic compounds that have a major role in the
treatment of various inflammatory diseases, including arthritis, gastritis, nephritis, hepatitis …

[HTML][HTML] Plants-based medicine implication in the evolution of chronic liver diseases

M Foghis, SG Bungau, AF Bungau, CM Vesa… - Biomedicine & …, 2023 - Elsevier
Hepatic disorders are considered major health problems, due to their high incidence,
increased risk of chronicling or death and the costs involved in therapies. A large number of …

Preformulation studies of myricetin: a natural antioxidant flavonoid

Y Yao, G Lin, Y Xie, P Ma, G Li… - Die Pharmazie-An …, 2014 - ingentaconnect.com
Myricetin is a natural flavonoid which has attracted great interest due to its antioxidant and
free-radical scavenging activities. Unfortunately, physicochemical properties of myricetin are …

Baicalein and baicalin alleviate acetaminophen-induced liver injury by activating Nrf2 antioxidative pathway: The involvement of ERK1/2 and PKC

L Shi, Z Hao, S Zhang, M Wei, B Lu, Z Wang… - Biochemical …, 2018 - Elsevier
Acetaminophen (APAP)-induced hepatotoxicity is the main cause of drug-induced liver
injury. This study investigated the protection of baicalin and its aglycone baicalein against …