The potential therapeutic effect of phosphodiesterase 5 inhibitors in the acute ischemic stroke (AIS)

R AlRuwaili, HM Al-Kuraishy, M Alruwaili… - Molecular and Cellular …, 2024 - Springer
Acute ischemic stroke (AIS) is a focal neurological disorder that accounts for 85% of all
stroke types, due to occlusion of cerebral arteries by thrombosis and emboli. AIS is also …

Advances in brain-heart syndrome: Attention to cardiac complications after ischemic stroke

M Wang, Y Peng - Frontiers in Molecular Neuroscience, 2022 - frontiersin.org
Neurocardiology is an emerging field that studies the interaction between the brain and the
heart, namely the effects of heart injury on the brain and the effects of brain damage on the …

Arginine derivatives in cerebrovascular diseases: mechanisms and clinical implications

GM Grosse, E Schwedhelm, H Worthmann… - International Journal of …, 2020 - mdpi.com
The amino acid L-arginine serves as substrate for the nitric oxide synthase which is crucial
in vascular function and disease. Derivatives of arginine, such as asymmetric (ADMA) and …

Hypoxanthine is a metabolic biomarker for inducing GSDME-dependent pyroptosis of endothelial cells during ischemic stroke

J Ye, X Bi, S Deng, X Wang, Z Liu, Q Suo, J Wu… - …, 2024 - pmc.ncbi.nlm.nih.gov
Rationale: Stroke induces metabolic changes in the body, and metabolites have become
potential biomarkers for stroke. However, the specific metabolites involved in stroke and the …

L-arginine pathway in COPD patients with acute exacerbation: a new potential biomarker

I Ruzsics, L Nagy, S Keki, V Sarosi, B Illes… - COPD: Journal of …, 2016 - Taylor & Francis
Background: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD)
remains a major cause of mortality. Clinical criteria of AECOPD are subjective. Biomarkers …

Temporal profiles of blood pressure, circulating nitric oxide, and adrenomedullin as predictors of clinical outcome in acute ischemic stroke patients

M Serrano‑Ponz… - Molecular …, 2016 - spandidos-publications.com
Stroke remains an important health and social challenge. The present study investigated
whether blood pressure (BP) parameters and circulating levels of nitric oxide metabolites …

Early dynamics of P-selectin and interleukin 6 predicts outcomes in ischemic stroke

G Pusch, B Debrabant, T Molnar, G Feher… - Journal of Stroke and …, 2015 - Elsevier
Background Thromboinflammatory molecules connect the prothrombotic state, endothelial
dysfunction, and systemic/local inflammation in the acute phase of ischemic stroke. Methods …

Adipose tissue and metabolic and inflammatory responses to stroke are altered in obese mice

MJ Haley, G Mullard, KA Hollywood… - Disease models & …, 2017 - journals.biologists.com
Obesity is an independent risk factor for stroke, although several clinical studies have
reported that obesity improves stroke outcome. Obesity is hypothesised to aid recovery by …

Blood-based biomarkers: a forgotten friend of Hyperacute ischemic Stroke

Z Liu, C Yang, X Wang, Y Xiang - Frontiers in neurology, 2021 - frontiersin.org
Ischemic stroke (IS) is the second leading cause of death worldwide. Multimodal
neuroimaging techniques that have significantly facilitated the diagnosis of hyperacute IS …

[HTML][HTML] The relation between GABA and L-arginine levels with some stroke risk factors in acute ischemic stroke patients

M Hosinian, D Qujeq, AA Ahangar - International Journal of …, 2016 - ncbi.nlm.nih.gov
Abstract Changes in extra and intracellular neurotransmitter amino acids concentration in
the early stage of acute cerebral ischemia have been reported. In this the study, serum level …