Osteoporosis, a condition of skeletal decline that undermines quality of life, is treated with
pharmacological interventions that are associated with poor adherence and adverse effects …

Lack of physical activity causes bone loss and fractures not only in elderly people, but also
in bedridden patients or otherwise inactive youth. This is fast becoming one of the most …

Aging and a sedentary lifestyle conspire to reduce bone quantity and quality, decrease
muscle mass and strength, and undermine postural stability, culminating in an elevated risk …

This paper presents a narrative review of research literature to “map the landscape” of the
mechanisms of the effect of sound vibration on humans including the physiological …

Bone material strength is determined by several factors, such as bone mass, matrix
composition, mineralization, architecture and shape. From a clinical perspective, bone …

Adaptation of bone to mechanical stresses normally produces a bone architecture that
combines a proper resistance against failure with a minimal use of material. This adaptive …

Plastin 3 (PLS3), a protein involved in the formation of filamentous actin (F-actin) bundles,
appears to be important in human bone health, on the basis of pathogenic variants in PLS3 …

Osteocytes are well evidenced to be the major mechanosensor in bone, responsible for
sending signals to the effector cells (osteoblasts and osteoclasts) that carry out bone …

A cell's ability to recognize and adapt to the physical environment is central to its survival
and function, but how mechanical cues are perceived and transduced into intracellular …

High‐frequency whole body vibrations can be osteogenic, but their efficacy appears limited
to skeletal segments that are weight bearing and thus subject to the induced load. To …