Damage‐associated molecular patterns (DAMPs) include endogenous intracellular
molecules released by activated or necrotic cells and extracellular matrix (ECM) molecules …

Extracellular matrix is a highly dynamic macromolecular network. Proteoglycans are major
components of extracellular matrix playing key roles in its structural organization and cell …

Cholangiocarcinoma (CCA) comprises a heterogeneous group of cancers with pathologic
features of biliary tract differentiation, and is presumed to arise from the intra-or extrahepatic …

Inflammation and autophagy have emerged as prominent issues in the context of
proteoglycan signaling. In particular, two small, leucine‐rich proteoglycans, biglycan and …

Proteoglycans control numerous normal and pathological processes, among which are
morphogenesis, tissue repair, inflammation, vascularization and cancer metastasis. During …

Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) are the major adult liver
cancers. The existence of combined hepatocellular-cholangiocarcinoma (CHC), a …

Intrahepatic cholangiocarcinoma is typically characterized by a dense desmoplastic stroma,
of which cancer-associated myofibroblasts (which express α-smooth muscle actin), are a …

Abstract microRNAs (miRNAs) are frequently dysregulated in human malignancies. It was
recently shown that miR-204-5p is downregulated in papillary thyroid carcinoma (PTC); …

Hepatocellular carcinoma (HCC) has a high incidence and dismal prognosis, making it a
significant global health burden. To change this, the development of new therapeutic …

The tumor matrix together with inflammation and autophagy are crucial regulators of cancer
development. Embedded in the tumor stroma are numerous proteoglycans which, in their …