RNA modifications have become hot topics recently. By influencing RNA processes,
including generation, transportation, function, and metabolization, they act as critical …

RNA tailing, or the addition of non-templated nucleotides to the 3′ end of RNA, is the most
frequent and conserved type of RNA modification. The addition of tails and their composition …

SARS-CoV-2 is a betacoronavirus responsible for the COVID-19 pandemic. Although the
SARS-CoV-2 genome was reported recently, its transcriptomic architecture is unknown …

The number of sequenced viral genomes has surged recently, presenting an opportunity to
understand viral diversity and uncover unknown regulatory mechanisms. Here, we …

MicroRNAs (miRNAs) associated with Argonaute proteins (AGOs) regulate gene expression
in mammals. miRNA 3'ends are subject to frequent sequence modifications, which have …

Mitochondria, often referred to as the powerhouses of cells, are vital organelles that are
present in almost all eukaryotic organisms, including humans. They are the key energy …

TENT4 enzymes generate 'mixed tails' of diverse nucleotides at 3′ ends of RNAs via
nontemplated nucleotide addition to protect messenger RNAs from deadenylation. Here we …

Premature transcription termination yields a wealth of unadenylated (pA−) RNA. Although
this can be targeted for degradation by the Nuclear EXosome Targeting (NEXT) complex …

The genetics of β-cell function (BCF) offer valuable insights into the aetiology of type 2
diabetes (T2D),. Previous studies have expanded the catalogue of BCF genetic associations …

TENT5C is a non-canonical cytoplasmic poly (A) polymerase highly expressed by activated
B cells to suppress their proliferation. Here we measure the global distribution of poly (A) tail …