Cholestatic liver disease is associated with widespread derangements in the cardiovascular
system, such as bradycardia, hypotension, QT prolongation and peripheral vasodilation; it is …

Changes in vascular responsiveness are proposed as the basis for some of the
cardiovascular complications in cholestasis. Cholestasis is also associated with …

Interaction between endogenous opioids and nitric oxide (NO) has been shown in different
biological models and pharmacological evidence suggest that opioids can induce NO …

Endogenous opioids have been reported to accumulate in the plasma of cholestatic
subjects. Another report showed that human osteoblast-like cells, MG-63, express 3 types of …

Background: Inflammatory bowel disorders are associated with increased incidence of
seizures. Alteration in the endogenous opioid system and overproduction of nitric oxide …

Endogenous opioids have nitric oxide (NO)‐dependent cardiovascular actions. In the light of
biological evidence of accumulation of endogenous opioids in cholestasis and also …

Acute cholestasis is associated with increased activity of the endogenous opioid system.
Agonists and antagonists of cholecystokinin (CCK) receptors are known to modulate opioid …

Nitric oxide (NO) and morphine have been coupled in many physiological as well as
pathological processes. The present study examined the involvement of the l-arginine/NO …

Background: Accumulation of endogenous opioids and overproduction of nitric oxide has
been reported in cholestatic mice. It is well known that endogenous opioids and nitric oxide …

Background and aim: Cholestatic animals display abnormal hypothalamic responses to
pyrogenic stimuli and decreased febrile response to lipopolysaccharide. The present study …