Proprotein convertase subtilisin/kexin type 9 (PCSK9) has evolved as a pivotal enzyme in
lipid metabolism and a revolutionary therapeutic target for hypercholesterolemia and its …

Vascular smooth muscle cells (VSMCs) are integral to the pathophysiology of cardiovascular
diseases (CVDs). Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase, plays a …

Background The frequency, characteristics, and outcomes of patients treated with high-
intensity lipid-lowering therapy and showing concomitant atheroma volume reduction, lipid …

Vascular diseases constitute a significant contributor to worldwide mortality rates, placing a
substantial strain on healthcare systems and socio-economic aspects. They are closely …

BACKGROUND: Interferon-γ (IFNγ) signaling plays a complex role in atherogenesis. IFNγ
stimulation of macrophages permits in vitro exploration of proinflammatory mechanisms and …

Cancer is a disease with a significant global burden in terms of premature mortality, loss of
productivity, healthcare expenditures, and impact on mental health. Recent decades have …

Vascular smooth muscle cells (VSMCs) are key participants in both early-and late-stage
atherosclerosis and influence neighbouring cells possibly by means of bioactive molecules …

Introduction Proprotein convertase subtilisin/kexin type 9 (PCSK9) is implicated in the
pathogenesis and progression of autoimmune disease. Patients with rheumatoid arthritis …

Atherosclerosis is a primary precursor of cardiovascular disease (CVD), the leading cause of
death worldwide. While proprotein convertase subtilisin/kexin 9 (PCSK9) contributes to CVD …

Macrophages are the basic mediators and coordinators of various types of chronic
inflammation and play a crucial role in the formation and development of atherosclerosis …