The primary cilium of telocytes in the vasculature: electron microscope imaging

I Cantarero, MJ Luesma… - Journal of cellular and …, 2011 - Wiley Online Library
Blood vessels are highly organized and complex structure, which are far more than simple
tubes conducting the blood to almost any tissue of the body. The fine structure of the wall of …

Axonemal positioning and orientation in three‐dimensional space for primary cilia: What is known, what is assumed, and what needs clarification

CE Farnum, NJ Wilsman - Developmental Dynamics, 2011 - Wiley Online Library
Two positional characteristics of the ciliary axoneme—its location on the plasma membrane
as it emerges from the cell, and its orientation in three‐dimensional (3D) space—are known …

[HTML][HTML] Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression

CM Tang, TE Lee, SA Syed, AM Burgoyne… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Gastrointestinal stromal tumors (GIST) arise within the interstitial cell of Cajal (ICC) lineage
due to activating KIT/PDGFRA mutations. Both ICC and GIST possess primary cilia (PC) …

Ultrastructural evidence for telocytes in equine tendon

MJ Luesma, I Cantarero, AI Sánchez‐Cano… - Journal of …, 2021 - Wiley Online Library
The three‐dimensional ultrastructure of the tendon is complex. Two main cell types are
classically supported: elongated tenocytes and ovoid tenoblasts. The existence of resident …

Hedgehog signalling pathway activation in gastrointestinal stromal tumours is mediated by primary cilia

P Iruzubieta, M Monzón, T Castiella, T Ramírez… - Gastric Cancer, 2020 - Springer
Background Gastrointestinal stromal tumour (GIST) is a mesenchymal cancer which derives
from interstitial cells of Cajal. To determine whether a relationship between Hedgehog (Hh) …

Primary cilia in gastric gastrointestinal stromal tumours (GISTs): an ultrastructural study

T Castiella, G Munoz, MJ Luesma… - Journal of Cellular …, 2013 - Wiley Online Library
Gastrointestinal stromal tumours (GIST s) are the most common mesenchymal (non‐
epithelial) neoplasms of the human gastrointestinal (GI) tract. They are thought to derive …

Enteric neurons show a primary cilium

MJ Luesma, I Cantarero, T Castiella… - Journal of cellular …, 2013 - Wiley Online Library
The primary cilium is a non‐motile cilium whose structure is 9+ 0. It is involved in co‐
ordinating cellular signal transduction pathways, developmental processes and tissue …

TALPID3/KIAA0586 regulates multiple aspects of neuromuscular patterning during gastrointestinal development in animal models and human

JM Delalande, N Nagy, CJ McCann… - Frontiers in Molecular …, 2021 - frontiersin.org
TALPID3/KIAA0586 is an evolutionary conserved protein, which plays an essential role in
protein trafficking. Its role during gastrointestinal (GI) and enteric nervous system (ENS) …

Supporting evidence of human enteric nervous system adult neurogenesis: presence of primary cilia and adult neurogenesis markers

P Iruzubieta, I Cantarero, M Monzón, M Lahoz… - Cellular and Molecular …, 2022 - Springer
Adult neurogenesis has been profusely studied in central nervous system. However, its
presence in enteric nervous system remains elusive although it has been recently …

[PDF][PDF] Primary cilia in gastrointestinal stromal tumors

J Dvorak, V Sitorova, DH Nikolov, A Filipova, A Ryska… - Neoplasma, 2014 - academia.edu
We observed 9985 nuclei of cells of GISTs and 425 primary cilia in total. The median of
frequency of primary cilia in cells of GISTs in all examined samples was 4.26%, in primary …