Despite the high prevalence of medicinal use and abuse of opioids, their neurobiology and
mechanisms of action are not fully understood. Experimental (animal) models are critical for …

Drug abuse and brain disorders related to drug comsumption are public health problems
with harmful individual and social consequences. The identification of therapeutic targets …

Research has recently demonstrated that larval zebrafish show similar molecular responses
to nociception to those of adults. Our study explored whether unprotected larval zebrafish …

Substance use disorder (SUD) is a chronic neuropsychiatric condition characterized by long-
lasting alterations in the neural circuitry regulating reward and motivation. Substantial work …

Percutaneous electrolysis is an emerging intervention proposed for the management of
tendinopathies. Tendon pathology is characterized by a significant cell response to injury …

This paper is the thirty-eighth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2015 …

In developmental toxicity, the evaluation of early biomarkers may be predictive of later
developmental outcomes. Over the last few years, new models have been proposed for …

Numerous studies have been published in the past years investigating the transcriptome of
the zebrafish embryo (ZFE) upon being subjected to chemical stress. Aiming at a more …

Genetic abnormalities affecting glutamate receptors are central to excitatory overload-driven
neuronal mechanisms that culminate in seizures, making them pivotal targets in epilepsy …

Opioid abuse continues to plague society, and in recent years, there has been an epidemic,
leading to increased addiction and death. It is poorly understood how prenatal opioid use …