Therapy resistance: opportunities created by adaptive responses to targeted therapies in cancer
Normal cells explore multiple states to survive stresses encountered during development
and self-renewal as well as environmental stresses such as starvation, DNA damage, toxins …
and self-renewal as well as environmental stresses such as starvation, DNA damage, toxins …
Artificial intelligence-based multi-omics analysis fuels cancer precision medicine
With biotechnological advancements, innovative omics technologies are constantly
emerging that have enabled researchers to access multi-layer information from the genome …
emerging that have enabled researchers to access multi-layer information from the genome …
[HTML][HTML] Single-cell RNA sequencing reveals a pro-invasive cancer-associated fibroblast subgroup associated with poor clinical outcomes in patients with gastric …
X Li, Z Sun, G Peng, Y Xiao, J Guo, B Wu, X Li… - Theranostics, 2022 - ncbi.nlm.nih.gov
Background: The protumor activities of cancer-associated fibroblasts (CAFs) suggest that
they are potential therapeutic targets for the treatment of cancer. The mechanism of CAF …
they are potential therapeutic targets for the treatment of cancer. The mechanism of CAF …
A single‐cell RNA expression atlas of normal, preneoplastic and tumorigenic states in the human breast
To examine global changes in breast heterogeneity across different states, we determined
the single‐cell transcriptomes of> 340,000 cells encompassing normal breast, preneoplastic …
the single‐cell transcriptomes of> 340,000 cells encompassing normal breast, preneoplastic …
Breast cancer heterogeneity and its implication in personalized precision therapy
L Guo, D Kong, J Liu, L Zhan, L Luo, W Zheng… - … hematology & oncology, 2023 - Springer
Breast cancer heterogeneity determines cancer progression, treatment effects, and
prognosis. However, the precise mechanism for this heterogeneity remains unknown owing …
prognosis. However, the precise mechanism for this heterogeneity remains unknown owing …
Long non-coding RNAs: the regulatory mechanisms, research strategies, and future directions in cancers
N Gao, Y Li, J Li, Z Gao, Z Yang, Y Li, H Liu… - Frontiers in …, 2020 - frontiersin.org
The development and application of whole genome sequencing technology has greatly
broadened our horizons on the capabilities of long non-coding RNAs (lncRNAs). LncRNAs …
broadened our horizons on the capabilities of long non-coding RNAs (lncRNAs). LncRNAs …
Spatial charting of single-cell transcriptomes in tissues
Single-cell RNA sequencing methods can profile the transcriptomes of single cells but
cannot preserve spatial information. Conversely, spatial transcriptomics assays can profile …
cannot preserve spatial information. Conversely, spatial transcriptomics assays can profile …
De novo detection of somatic mutations in high-throughput single-cell profiling data sets
Abstract Characterization of somatic mutations at single-cell resolution is essential to study
cancer evolution, clonal mosaicism and cell plasticity. Here, we describe SComatic, an …
cancer evolution, clonal mosaicism and cell plasticity. Here, we describe SComatic, an …
Exosomes in the hypoxic TME: from release, uptake and biofunctions to clinical applications
G He, X Peng, S Wei, S Yang, X Li, M Huang, S Tang… - Molecular Cancer, 2022 - Springer
Hypoxia is a remarkable trait of the tumor microenvironment (TME). When facing selective
pressure, tumor cells show various adaptive characteristics, such as changes in the …
pressure, tumor cells show various adaptive characteristics, such as changes in the …
Recent developments in application of single-cell RNA sequencing in the tumour immune microenvironment and cancer therapy
The advent of single-cell RNA sequencing (scRNA-seq) has provided insight into the tumour
immune microenvironment (TIME). This review focuses on the application of scRNA-seq in …
immune microenvironment (TIME). This review focuses on the application of scRNA-seq in …