Abstract The INK4b–ARF–INK4a locus encodes two members of the INK4 family of cyclin-
dependent kinase inhibitors, p15 INK4b and p16 INK4a, and a completely unrelated protein …

Polycomb group proteins (PcG) form part of a gene regulatory mechanism that determines
cell fate during normal and pathogenic development. The mechanism relies on epigenetic …

The Ink4a/Arf locus encodes 2 tumor suppressor molecules, p16INK4a and Arf, which are
principal mediators of cellular senescence. To study the links between senescence and …

Aberrant transcriptional repression through chromatin remodelling and histone
deacetylation has been postulated to represent a driving force underlying tumorigenesis …

Aging is a major risk factor for tendon injury and impaired tendon healing, but the basis for
these relationships remains poorly understood. Here we show that rat tendon‐derived …

We have developed an in situ bioprinting method that allows the printing of cells under true
physiological conditions by applying self-assembling ultrashort peptides as bioinks. This …

The Saccharomyces cerevisiae chromatin silencing factor Sir2 suppresses genomic
instability and extends replicative life span. In contrast, we find that mouse embryonic …

Malformations of the septum, outflow tract and aortic arch are the most common congenital
cardiovascular defects and occur in mice lacking Cited2, a transcriptional coactivator of …

Rationale: Premature ovarian insufficiency (POI) is an accelerated reduction in ovarian
function inducing infertility. Folliculogenesis defects have been reported to trigger POI as a …

Abstract Polycomb Group (PcG) proteins form Polycomb Repressive Complexes (PRCs) that
function as epigenetic repressors of gene expression. The large variety of PcG proteins, in …