The cascade of amyloid formation relates to multiple complex events at the molecular level.
Previous research has established amyloid plaque deposition as the leading cause of …

Neurodegenerative diseases (NDDs) are incurable and debilitating conditions that result in
progressive degeneration and/or death of nerve cells in the central nervous system (CNS) …

Cellular deposition of protein aggregates, one of the hallmarks of neurodegeneration,
disrupts cellular functions and leads to neuronal death. Mutations, posttranslational …

Amyloid fibrils are associated with a number of neurodegenerative diseases, including fibrils
of amyloid β42 peptide (Aβ42) in Alzheimer's disease. These fibrils are a source of toxicity to …

The accumulation of the amyloid‐β peptides (Aβ) is central to the development of
Alzheimer's disease. The mechanism by which Aβ triggers a cascade of events that leads to …

In a three-dimensional (3D) representation, each protein molecule displays a specific
pattern of chemical and topological features, which are altered during its misfolding and …

Protein nanotubes (PNTs) as state‐of‐the‐art nanocarriers are promising for various
potential applications both in the food and pharmaceutical industries. Derived from edible …

Protein function and flexibility is directly related to the native distribution of its structural
elements and any alteration in protein architecture leads to several abnormalities and …

Amyloid plaques composed of Aβ fibrils are a hallmark of Alzheimer's disease (AD).
However, the molecular architecture of amyloid plaques in the context of fresh mammalian …

Proteins unfold in chaotropic salt solutions, a process that is difficult to observe at the single
protein level. The work presented here demonstrates that a liquid-based atomic force …