Inflammatory responses after ischemic stroke

JH DeLong, SN Ohashi, KC O'Connor… - Seminars in …, 2022 - Springer
Ischemic stroke generates an immune response that contributes to neuronal loss as well as
tissue repair. This is a complex process involving a range of cell types and effector …

Understanding the connection between common stroke comorbidities, their associated inflammation, and the course of the cerebral ischemia/reperfusion cascade

Ł Przykaza - Frontiers in immunology, 2021 - frontiersin.org
Despite the enormous progress in the understanding of the course of the ischemic stroke
over the last few decades, a therapy that effectively protects neurovascular units (NVUs) and …

Neutrophils—from bone marrow to first-line defense of the innate immune system

RF Kraus, MA Gruber - Frontiers in immunology, 2021 - frontiersin.org
Neutrophils (polymorphonuclear cells; PMNs) form a first line of defense against pathogens
and are therefore an important component of the innate immune response. As a result of …

Caveolin-1 accelerates hypoxia-induced endothelial dysfunction in high-altitude cerebral edema

Y Xue, X Wang, B Wan, D Wang, M Li, K Cheng… - Cell Communication and …, 2022 - Springer
Background High-altitude cerebral edema (HACE) is a serious and potentially fatal brain
injury that is caused by acute hypobaric hypoxia (HH) exposure. Vasogenic edema is the …

Targeting vascular inflammation through emerging methods and drug carriers

J Nong, PM Glassman, VR Muzykantov - Advanced drug delivery reviews, 2022 - Elsevier
Acute inflammation is a common dangerous component of pathogenesis of many prevalent
conditions with high morbidity and mortality including sepsis, thrombosis, acute respiratory …

Signaling pathways in brain ischemia: Mechanisms and therapeutic implications

W Lin, XY Zhao, J Cheng, L Li, Q Jiang… - Pharmacology & …, 2023 - Elsevier
Ischemic stroke occurs when the arteries supplying blood to the brain are narrowed or
blocked, inducing damage to brain tissue due to a lack of blood supply. One effective way to …

[HTML][HTML] Cell heterogeneity uncovered by single-cell RNA sequencing offers potential therapeutic targets for ischemic stroke

M Qiu, J Zong, Q He, Y Liu, Y Wan, M Li, Y Zhou… - Aging and …, 2022 - ncbi.nlm.nih.gov
Ischemic stroke is a detrimental neurological disease characterized by an irreversible infarct
core surrounded by an ischemic penumbra, a salvageable region of brain tissue. Unique …

Lung megakaryocytes engulf inhaled airborne particles to promote intrapulmonary inflammation and extrapulmonary distribution

J Qiu, J Ma, Z Dong, Q Ren, Q Shan, J Liu… - Nature …, 2024 - nature.com
Many lung immune cells are known to respond to inhaled particulate matter. However,
current known responses cannot explain how particles induce thrombosis in the lung and …

Cell membrane nanomaterials composed of phospholipids and glycoproteins for drug delivery in inflammatory bowel disease: a review

P Lei, H Yu, J Ma, J Du, Y Fang, Q Yang… - International journal of …, 2023 - Elsevier
Inflammatory bowel disease (IBD) is a serious chronic intestinal disorder with an increasing
global incidence. However, current treatment strategies, such as anti-inflammatory drugs …

A strong adhesive biological hydrogel for colon leakage repair and abdominal adhesion prevention

Q Mao, Z Huang, Y Zhang, Q Chen… - Advanced …, 2023 - Wiley Online Library
Colon leakage is one of the most severe complications in abdominal trauma or surgery
cases. It can lead to severe abdominal infection and abdominal adhesions, resulting in …