In this review, we address the interplay between the complement system and host
microbiomes in health and disease, focussing on oral bacteria known to contribute to …

The human complement system is an important part of the innate immune response in the
fight against invasive bacteria. Complement responses can be activated independently by …

Mucus barriers accommodate trillions of microorganisms throughout the human body while
preventing pathogenic colonization. In the oral cavity, saliva containing the mucins MUC5B …

Recent studies have demonstrated a relationship between oral bacteria and systemic
inflammation. Endothelial cells (ECs), which line blood vessels, control the opening and …

Streptococcus sanguinis is a ubiquitous commensal species of the oral cavity commonly
involved as an opportunistic pathogen in cardiovascular infections. In this study, we …

Bacterial surface proteins assembled into amyloids contribute to biofilm formation and host
immune evasion. Streptococcus sanguinis, a pioneer colonizer of teeth commonly involved …

Background Streptococcus suis serotype 2 (S. suis 2) is an important zoonotic pathogen.
Orphan response regulator CovR plays crucial regulative functions in the survivability and …

Streptococcus sanguinis is a pioneer commensal species of dental biofilms, abundant in
different oral sites and commonly associated with opportunist cardiovascular infections. In …

Early childhood caries (ECC), a severe form of caries due to cross-kingdom interaction of
Candida albicans and Streptococcus mutans, is a serious childhood dental disease that …

The Gram-positive bacterial species Streptococcus suis is an important porcine and human
pathogen that causes severe life-threatening diseases associated with high mortality rates …