In chronic infection, inflammation and cancer, the tissue microenvironment controls how
local immune cells behave, with tissue-resident fibroblasts emerging as a key cell type in …

Chemokines mediate numerous physiological and pathological processes related primarily
to cell homing and migration. The chemokine CXCL12, also known as stromal cell-derived …

Fibroblasts, which are traditionally recognized as a quiescent cell responsible for
extracellular matrix production, are more and more appreciated as an active key player of …

It is now well accepted that plasma cells can become long-lived (memory) plasma cells and
secrete antibodies for months, years or a lifetime. However, the mechanisms involved in this …

The vascular adventitia acts as a biological processing center for the retrieval, integration,
storage, and release of key regulators of vessel wall function. It is the most complex …

Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation
in joints, associated with synovial hyperplasia and with bone and cartilage destruction …

Chemokine receptors are members of the G protein-coupled receptor superfamily. These
receptors are intimately involved in cell movement, and thus play a critical role in several …

Understanding the developmental mechanisms of follicular helper T cells (TFH cells) in
humans is relevant to the clinic. However, the factors that drive the differentiation of human …

We examine here several diseases that are associated with inappropriate activation of the
chemokine network. Detailed comment has been restricted to pathological states for which …

Combined phylogenetic and chromosomal location studies suggest that the orphan receptor
RDC1 is related to CXC chemokine receptors. RDC1 provides a co-receptor function for a …