Stochastic cell fate specification, in which a cell chooses between two or more fates with a
set probability, diversifies cell subtypes in development. Although this is a vital process …

Enhancers in metazoan genomes are known to activate their target genes across both short
and long genomic distances. Recent advances in chromosome conformation capture assays …

Proper expression of odor receptor genes is critical for the function of olfactory systems. In
this study, we identified exitrons (exonic introns) in four of the 39 Odorant receptor (Or) …

The immune system is highly regulated but, when dysregulated, suboptimal protective or
overly robust immune responses can lead to immune-mediated disorders. The genetic and …

In a recent study, Pourmorady and colleagues uncovered a noncoding role for olfactory
receptor (OR)-coding mRNA in mediating nuclear architecture and singular OR choice. The …

This Review elucidates the regulatory principles of random monoallelic expression by
focusing on two well-studied examples: the X-chromosome inactivation regulator Xist and …

The mammalian sense of smell relies upon a vast array of receptor proteins to detect
odorant compounds present in the environment. The proper deployment of these receptor …

Olfactory sensory neurons (OSNs) are one of a few neuron types that are generated
continuously throughout life in mammals. The persistence of olfactory sensory neurogenesis …

The sense of smell is intricately linked to essential animal behaviors necessary for individual
survival and species preservation. During vertebrate evolution, odorant receptors (ORs) …

Over the last few decades, novel methods have been developed to study how chromosome
positioning within the nucleus may play a role in gene regulation. Adaptation of these …