Iron overload and iron toxicity, whether because of increased absorption or iron loading from
repeated transfusions, can be major causes of morbidity and mortality in a number of chronic …

Beyond the disorders recognized as mitochondrial diseases, abnormalities in function
and/or ultrastructure of mitochondria have been reported in several unrelated pathologies …

Human exonuclease 1 (EXO1), a 5′→ 3′ exonuclease, contributes to the regulation of the
cell cycle checkpoints, replication fork maintenance, and post replicative DNA repair …

Xeroderma pigmentosum is a rare autosomal recessive disease that is associated with a
severe deficiency in nucleotide excision repair. The presence of a distinct the nucleotide …

The etiology of hepatoblastoma is largely unknown due to the rarity of this disease.
Nucleotide excision repair (NER), a versatile system in repairing DNA damage, is highly …

Background Few high penetrance genes are known in Malignant Melanoma (MM), however,
the involvement of low-penetrance genes such as MC1R, OCA2, ASIP, SLC45A2 and TYR …

Both endogenous factors (genomic variations) and exogenous factors (environmental
exposures, lifestyle) impact the balance of reactive oxygen species (ROS). Variants of the …

Nitric oxide (NO) triggers multiple signal transduction pathways and contributes to the
control of numerous cellular functions. Previous studies have shown in model organisms …

Background A growing body of evidence indicates that oxidative stress, high levels of
reactive oxygen species (ROS), is implicated in the pathogenesis of breast cancer (BC) …

Background Steadily high melanoma mortality rates urge for the availability of novel
biomarkers with a more personalized ability to predict melanoma clinical outcomes …