Inflammasomes are innate immune signaling pathways that sense pathogens and injury to
direct the proteolytic maturation of inflammatory cytokines such as IL‐1β and IL‐18. Among …

Malaria is a significant public health problem in more than 100 countries and causes an
estimated 200 million new infections every year. Despite the significant effort to eradicate …

Greater than 80% of malaria-related mortality occurs in sub-Saharan Africa due to infections
with Plasmodium falciparum. The majority of P. falciparum-related mortality occurs in …

Hemozoin (HZ) is an insoluble crystal formed in the food vacuole of malaria parasites. HZ
has been reported to induce inflammation by directly engaging Toll-like receptor (TLR) 9, an …

The intraerythrocytic parasite Plasmodium—the causative agent of malaria—produces an
inorganic crystal called hemozoin (Hz) during the heme detoxification process, which is …

MRI phase imaging in multiple sclerosis (MS) patients and in autopsy tissue have
demonstrated the presence of iron depositions in white matter lesions. The accumulation of …

Hemozoin (Hz) is the crystalline detoxification product of hemoglobin in Plasmodium-
infected erythrocytes. We previously proposed that Hz can carry plasmodial DNA into a …

Background and purpose: 5α, 8α‐Epidioxy‐22E‐ergosta‐6, 22‐dien‐3β‐ol (ergosterol
peroxide) is a major antitumour sterol produced by edible or medicinal mushrooms …

Malaria is a deadly infectious disease caused by the intraerythrocytic protozoan parasite
Plasmodium. The four species of Plasmodium known to affect humans all produce an …

The role of proinflammatory cytokine production in the pathogenesis of malaria is well
established, but the identification of the parasite products that initiate inflammation is not …