The nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3)
inflammasome is an important part of the natural immune system that plays an important role …

G protein-coupled estrogen receptor 1 (GPER1), is a functional estrogen receptor involved
in estrogen related actions on several systems including processes of the nervous …

The pathogenesis of obesity-associated cardiovascular diseases begins long prior to the
presentation of a cardiovascular event. In both men and women, cardiovascular events, and …

In modern society, cardiovascular disease remains the biggest single threat to life, being
responsible for approximately one third of worldwide deaths. Male prevalence is significantly …

17β-Estradiol (E2) is the main estrogenic hormone in the body and exerts many
cardiovascular protective effects. Via three receptors known to date, including estrogen …

Nearly 80% of all breast cancers are estrogen receptor positive (ER+) and require the
activity of this transcription factor for tumor growth and survival. Thus, endocrine therapies …

Abstract Purpose of Review Angiotensin-converting enzyme 2 (ACE2), a specific high-
affinity angiotensin II-hydrolytic enzyme, is the vector that facilitates cellular entry of SARS …

Introduction The transmasculine and gender diverse (TMGD) spectrum includes transgender
men and non-binary individuals whose sex was assigned female at birth. Many TMGD …

Heart failure (HF) is a significant public health problem worldwide. It has long been noted
that premenopausal women, compared to postmenopausal women and men, have lower …

Chronic pain is a worldwide refractory health disease that causes major financial and
emotional burdens and that is devastating for individuals and society. One primary source of …