Purpose The case‐crossover design is a self‐controlled study design used to compare
exposure immediately preceding an event occurrence with exposure in earlier control …

Background Medications influencing the risk of fall-related injuries (FRIs) in older adults
have been inconsistent in previous guidelines. This study employed case–control design to …

Decades after the case-crossover (CCO) design was first described [1], recent studies of
potential biases and alternative applications of CCO analyses using pharmaceutical and …

Observational studies are an important study design in pharmacoepidemiology research
especially when examining the safety of medications. Compared to randomized controlled …

2 Contracts between the sponsor and research organisation (s) and approvals by data
protection, data custodian, ethics, and scientific review bodies are pending. Timelines may …