Chemical synapses in the brain connect neurons to form neural circuits, providing the
structural and functional bases for neural communication. Disrupted synaptic signaling is …

RNA sequencing analyses are often limited to identifying lowest p value transcripts, which
does not address polygenic phenomena. To overcome this limitation, we developed an …

Schizophrenia (SZ) is a heritable brain disease originating from a complex interaction of
genetic and environmental factors. The genes underpinning the neurobiology of SZ are …

Structural gray matter (GM) volume reductions in patients with schizophrenia have rarely
been replicated across two different sites, the impact of culture and clinical characteristics …

Atypical psychosis (similar to acute and transient psychotic disorder, brief psychotic
disorder) is highly heritable, but the causal genes remain unidentified. We conducted whole …

Background Schizophrenia, a chronic severe psychiatric illness of unknown aetiology, has
been shown to be associated with HLA alleles but at varied degree in different population …

Background Molecular multi-omics data provide an in-depth view on biological systems, and
their integration is crucial to gain insights in complex regulatory processes. These data can …

Psychiatric genetic studies have uncovered hundreds of loci associated with various
psychiatric disorders. We take the opportunity to review achievements in the past and …

Recent reports revealed massive overlaps between the molecular pathologies of
schizophrenia (SCZ) and bipolar disorder (BD), but did not address the prominent clinical …

Genome-wide association studies (GWAS) have been performed for many human complex
traits, but for most of the risk loci the causal variants and the underlying molecular …