Background. Platinum-based anticancer drugs are widely used in the chemotherapy of
human neoplasms. The major obstacle for the clinical use of this class of drugs is the …

The failure of chemotherapy is a major challenge nowadays, and in order to ensure effective
treatment of cancer patients, it is of great importance to reveal the molecular pathways and …

Metals are essential in many biological processes, and metal ions are modeled in roughly
40% of the macromolecular structures in the Protein Data Bank (PDB). However, a …

Metal ions bound to macromolecules play an integral role in many cellular processes. They
can directly participate in catalytic mechanisms or be essential for the structural integrity of …

Human serum albumin (HSA) is a monomeric, globular, multi-carrier and the most abundant
protein in the blood. HSA displays multiple ligand binding sites with extraordinary binding …

The understanding of the role of vanadium enzymes and of vanadium compounds (VCs) in
biology, as well as the design of new vanadium-based species for catalysis, materials …

Copper and zinc are micronutrients that play a crucial role in many cellular pathways, act as
cofactors in enzymatic systems, and hence, modulate enzyme activity. The regulation of …

As the second most abundant trace element in the human body, zinc nutrition is constantly a
hot topic. More than one-third population is suffering zinc deficiency, which results in various …

Metals have crucial roles in many physiological, pathological, toxicological, pharmaceutical,
and diagnostic processes. Proper handling of metal-containing macromolecule samples for …

An outbreak of a novel coronavirus (COVID‐19 or 2019‐CoV) infection has posed significant
threats to international health and the economy. Patients with COVID‐19 are at risk of …