BK virus maintains a latent infection that is ubiquitous in humans. It has a propensity for
reactivation in the setting of a dysfunctional cellular immune response and is frequently …

BK polyomavirus (BKPyV) infection represents a major problem in transplantation,
particularly for renal recipients developing polyomavirus-associated nephropathy (PyVAN) …

It has been suggested that BK‐polyomavirus is linked to oncogenesis via high expression
levels of large T‐antigen in some urothelial neoplasms arising following kidney …

Bladder cancer (BC) is a complex disease affecting the urinary system and is regulated by
several carcinogenic factors. Viral infection is one such factor that has attracted extensive …

Background Systemic inflammatory response has been shown to play a vital role in
carcinogenesis and tumor progression. Acute rejection is a systemic inflammatory state and …

Recent case series describe detection of BK polyomavirus (BKV) in urinary tract cancers in
kidney transplant recipients, suggesting that BKV could contribute to the development of …

Human polyomaviruses are ubiquitous, with primary infections that typically occur during
childhood and subsequent latency that may last a lifetime. Polyomavirus‐mediated disease …

About 40 years ago, the large and small tumor antigens (LT-Ag and sT-Ag) of the
polyomavirus (PyVs) simian vacuolating virus 40 have been identified and characterized. To …

Background Solid organ transplant recipients are at increased risk for developing
malignancies. Polyomaviruses (PV) have been historically associated with experimental …

Several (pre-) clinical trials are currently investigating the benefit of HER2-targeted therapy
in urothelial bladder cancer (UBC). Patients with HER2 amplified UBC could potentially …