[HTML][HTML] Protective effects of curcumin against traumatic brain injury

D Khayatan, SM Razavi, ZN Arab, AH Niknejad… - Biomedicine & …, 2022 - Elsevier
Neuroinflammation is a key pathophysiological mechanism implicated in the
neurodegenerative condition. One such condition implicating neuroinflammation is traumatic …

Repurposing of tibolone in Alzheimer's disease

GE Barreto - Biomolecules, 2023 - mdpi.com
Alzheimer's disease (AD) is a debilitating neurodegenerative disease characterised by the
accumulation of amyloid-beta and tau in the brain, leading to the progressive loss of memory …

Mitochondria dysfunction and inflammation in traumatic brain injury: androgens to the battlefront

AJ McGovern, GE Barreto - Androgens: Clinical Research and …, 2021 - liebertpub.com
The therapeutic response to traumatic brain injury (TBI) still lacks a strategy to treat its acute
and chronic phases. Given that TBI affects the lives of 1.5 million people a year, and the …

[HTML][HTML] Network pharmacology and topological analysis on tibolone metabolites and their molecular mechanisms in traumatic brain injury

GE Barreto, J Gonzalez, D Ramírez - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Traumatic brain injury (TBI) is a pathology of great social impact, affecting millions of people
worldwide. Despite the scientific advances to improve the management of TBI in recent …

Network pharmacology and molecular docking analysis on potential molecular targets and mechanism of action of BRAF inhibitors for application in wound healing

S Karhana, S Dabral, A Garg, A Bano… - Journal of Cellular …, 2023 - Wiley Online Library
Topical application of BRAF inhibitors has been shown to accelerate wound healing in
murine models, which can be extrapolated into clinical applications. The aim of the study …

[HTML][HTML] Hydroxychloroquine alleviates renal interstitial fibrosis by inhibiting the PI3K/Akt signaling pathway

D Li, K Yu, F Feng, Y Zhang, F Bai, Y Zhang… - Biochemical and …, 2022 - Elsevier
Renal fibrosis is the ultimate presentation of chronic kidney disease, which progresses to
end-stage renal disease. Hydroxychloroquine (HCQ) has been adapted for the treatment of …

A novel network pharmacology strategy based on the universal effectiveness-common mechanism of medical herbs uncovers therapeutic targets in traumatic brain …

Z Yu, R Ding, Q Yan, M Cheng, T Li… - Drug design …, 2024 - Taylor & Francis
Purpose Many herbs can promote neurological recovery following traumatic brain injury
(TBI). There must lie a shared mechanism behind the common effectiveness. We aimed to …

Colloidal therapeutics in the management of traumatic brain injury: Portray of biomarkers and drug-targets, preclinical and clinical pieces of evidence and future …

S Arya, D Bahuguna, G Bajad, S Loharkar… - Colloids and Surfaces B …, 2023 - Elsevier
Complexity associated with the aberrant physiology of traumatic brain injury (TBI) makes its
therapeutic targeting vulnerable. The underlying mechanisms of pathophysiology of TBI are …

[HTML][HTML] Identification of HMGCR, PPGARG and prohibitin as potential druggable targets of dihydrotestosterone for treatment against traumatic brain injury using …

AJ McGovern, J Gonzalez, D Ramírez… - International …, 2022 - Elsevier
Abstract Background Traumatic Brain Injury (TBI) has long-term devastating effects for which
there is no accurate and effective treatment for inflammation and chronic oxidative stress. As …

[HTML][HTML] Role of statins in regulating molecular pathways following traumatic brain injury: A system pharmacology study

A Mahmoudi, S Heydari, YV Markina, GE Barreto… - Biomedicine & …, 2022 - Elsevier
Traumatic brain injury (TBI) is a serious disorder with debilitating physical and psychological
complications. Previous studies have indicated that genetic factors have a critical role in …