Tumour immunity: effector response to tumour and role of the microenvironment
A Mantovani, P Romero, AK Palucka, FM Marincola - The lancet, 2008 - thelancet.com
Substantial evidence shows that inflammation promotes oncogenesis and, occasionally,
participates in cancer rejection. This paradox can be accounted for by a dynamic switch from …
participates in cancer rejection. This paradox can be accounted for by a dynamic switch from …
WT1 (Wilms' tumor gene 1): biology and cancer immunotherapy
H Sugiyama - Japanese journal of clinical oncology, 2010 - academic.oup.com
Wilms' tumor gene WT1 encodes a transcription factor and plays an important role in cell
growth and differentiation. The WT1 gene is highly expressed in leukemia and various types …
growth and differentiation. The WT1 gene is highly expressed in leukemia and various types …
Leukemia-associated antigen-specific T-cell responses following combined PR1 and WT1 peptide vaccination in patients with myeloid malignancies
K Rezvani, ASM Yong, S Mielke… - Blood, The Journal …, 2008 - ashpublications.org
We describe the safety and immunogenicity of a combined vaccine of 2 leukemia-associated
antigenic peptides, PR1 and WT1. Eight patients with myeloid malignancies received one …
antigenic peptides, PR1 and WT1. Eight patients with myeloid malignancies received one …
Vaccination with synthetic analog peptides derived from WT1 oncoprotein induces T-cell responses in patients with complete remission from acute myeloid leukemia
PG Maslak, T Dao, LM Krug, S Chanel… - Blood, The Journal …, 2010 - ashpublications.org
A pilot study was undertaken to assess the safety, activity, and immunogenicity of a
polyvalent Wilms tumor gene 1 (WT1) peptide vaccine in patients with acute myeloid …
polyvalent Wilms tumor gene 1 (WT1) peptide vaccine in patients with acute myeloid …
WT1 peptide vaccine for the treatment of cancer
Y Oka, A Tsuboi, Y Oji, I Kawase… - Current opinion in …, 2008 - Elsevier
Wilms' tumor gene WT1 is expressed in various kinds of cancers. Human WT1-specific
cytotoxic T lymphocytes (CTLs) were generated, and mice immunized with WT1 peptide …
cytotoxic T lymphocytes (CTLs) were generated, and mice immunized with WT1 peptide …
Active specific immunotherapy targeting the Wilms' tumor protein 1 (WT1) for patients with hematological malignancies and solid tumors: lessons from early clinical …
A Van Driessche, ZN Berneman… - The oncologist, 2012 - academic.oup.com
Abstract Learning Objectives After completing this course, the reader will be able to: Explain
the role of the Wilm's tumor protein 1 (WT1) as a tumor antigen in peptide-and dendritic cell …
the role of the Wilm's tumor protein 1 (WT1) as a tumor antigen in peptide-and dendritic cell …
Analysis and characterization of antitumor T-cell response after administration of dendritic cells loaded with allogeneic tumor lysate to metastatic melanoma patients
N Bercovici, N Haicheur, S Massicard… - Journal of …, 2008 - journals.lww.com
The primary goal of cancer vaccines is to induce CD8+ T cells specific for tumor-associated
antigens (TAA) but the characterization of these cells has been difficult because of the low …
antigens (TAA) but the characterization of these cells has been difficult because of the low …
Peptide Epitopes from the Wilms' Tumor 1 Oncoprotein Stimulate CD4+ and CD8+ T Cells That Recognize and Kill Human Malignant Mesothelioma Tumor Cells
RJ May, T Dao, J Pinilla-Ibarz, T Korontsvit… - Clinical Cancer …, 2007 - AACR
Abstract Purpose: Wilms' tumor 1 protein (WT1), a transcription factor overexpressed in
malignant mesothelioma, leukemias, and other solid tumors, is an ideal target for …
malignant mesothelioma, leukemias, and other solid tumors, is an ideal target for …
WT1 expression in breast cancer disrupts the epithelial/mesenchymal balance of tumour cells and correlates with the metabolic response to docetaxel
M Artibani, AH Sims, J Slight, S Aitken, A Thornburn… - Scientific reports, 2017 - nature.com
WT1 is a transcription factor which regulates the epithelial-mesenchymal balance during
embryonic development and, if mutated, can lead to the formation of Wilms' tumour, the most …
embryonic development and, if mutated, can lead to the formation of Wilms' tumour, the most …
WT1 (Wilms' tumor 1) peptide immunotherapy for renal cell carcinoma
T Iiyama, K Udaka, S Takeda… - Microbiology and …, 2007 - Wiley Online Library
Tumor‐specific immunotherapy with a Wilms' tumor 1 (WT1) peptide has been on clinical
trial for leukemia, myelodysplastic syndrome, breast and lung cancers and is producing …
trial for leukemia, myelodysplastic syndrome, breast and lung cancers and is producing …