The heart is the central organ of the circulatory system, and its proper development is vital
for maintaining human life. Here, we used single-cell RNA sequencing to profile the gene …

Activation of complex molecular programs in specific cell lineages governs mammalian
heart development, from a primordial linear tube to a four-chamber organ. To characterize …

Embryonic gene expression intricately reflects anatomical context, developmental stage,
and cell type. To address whether the precise spatial origins of cardiac cells can be deduced …

Rationale: The cardiac conduction system (CCS) consists of distinct components including
the sinoatrial node, atrioventricular node, His bundle, bundle branches, and Purkinje fibers …

Congenital heart defects can be caused by mutations in genes that guide cardiac lineage
formation. Here, we show deletion of NKX2-5, a critical component of the cardiac gene …

Irisin, a newly identified hormone and cardiokine, is critical for modulating body metabolism.
New evidence indicates that irisin protects the heart against myocardial ischemic injury …

The recent development of single cell gene expression technologies, and especially single
cell transcriptomics, have revolutionized the way biologists and clinicians investigate organs …

Generating cardiomyocytes (CMs) from human induced pluripotent stem cells (hiPSCs) has
represented a significant advance in our ability to model cardiac disease. Current …

The burgeoning field of single-cell transcriptomics augments our ability to scrutinize organ
systems at unprecedented resolutions. Single-cell RNA sequencing (scRNA-seq) and …

Novel regenerative therapies may stem from deeper understanding of the mechanisms
governing cardiovascular lineage diversification. Using enhancer mapping and live imaging …