Retinal development and maturation are orchestrated by a series of interacting signalling
networks that drive the morphogenetic transformation of the anterior developing brain …

The development of the vertebrate eyes is a complex process starting from anterior-posterior
and dorso-ventral patterning of the anterior neural tube, resulting in the formation of the eye …

Numerous protocols have been described for producing neural retina from human
pluripotent stem cells (hPSCs), many of which are based on the culture of 3D organoids …

Transplantation of rod photoreceptors, derived either from neonatal retinae or pluripotent
stem cells (PSCs), can restore rod-mediated visual function in murine models of inherited …

Mutations in pre-mRNA processing factors (PRPFs) cause autosomal-dominant retinitis
pigmentosa (RP), but it is unclear why mutations in ubiquitously expressed genes cause non …

Once human photoreceptors die, they do not regenerate, thus, photoreceptor transplantation
has emerged as a potential treatment approach for blinding diseases. Improvements in …

Human induced pluripotent stem cells (hiPSCs) are potentially useful in regenerative
therapies for retinal disease. For medical applications, therapeutic retinal cells, such as …

The availability of in vitro models of the human retina in which to perform pharmacological
and toxicological studies is an urgent and unmet need. An essential step for developing in …

The eye is a complex organ with highly specialized constituent tissues derived from different
primordial cell lineages. The retina, for example, develops from neuroectoderm via the optic …

Inherited retinal diseases (IRDs) cause progressive loss of light-sensitive photoreceptors in
the eye and can lead to blindness. Gene-based therapies for IRDs have shown remarkable …